| Title |
Inhibitor of growth-4 is a potential target for cancer therapy
|
|---|---|
| Published in |
Tumor Biology, January 2016
|
| DOI | 10.1007/s13277-016-4842-3 |
| Pubmed ID | |
| Authors |
Shuping Yuan, Jianhua Jin, Juanjuan Shi, Yongzhong Hou |
| Abstract |
The inhibitor of growth-4 (ING-4) belongs to the inhibitor of growth (ING) family that is a type II tumor suppressor gene including five members (ING1-5). As a tumor suppressor, ING4 inhibits tumor growth, invasion, and metastasis by multiple signaling pathways. In addition to that, ING4 can facilitate cancer cell sensitivity to chemotherapy and radiotherapy. Although ING4 loss is observed for many types of cancers, increasing evidences show that ING4 can be used for gene therapy. In this review, the recent progress of ING4 regulating tumorigenesis is discussed. |
Mendeley readers
The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Turkey | 1 | 9% |
| Unknown | 10 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 45% |
| Student > Ph. D. Student | 3 | 27% |
| Professor | 1 | 9% |
| Student > Postgraduate | 1 | 9% |
| Unknown | 1 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 45% |
| Biochemistry, Genetics and Molecular Biology | 3 | 27% |
| Medicine and Dentistry | 1 | 9% |
| Unknown | 2 | 18% |