| Title |
The challenge of targeting metastasis
|
|---|---|
| Published in |
Cancer and Metastasis Reviews, September 2015
|
| DOI | 10.1007/s10555-015-9586-9 |
| Pubmed ID | |
| Authors |
Isaiah J. Fidler, Margaret L. Kripke |
| Abstract |
Metastases that are resistant to conventional therapy are the major cause of death from cancer. In most patients, metastasis has already occurred by the time of diagnosis. Thus, the prevention of metastasis is unlikely to be of therapeutic benefit. The biological heterogeneity of metastases presents a major obstacle to treatment. However, the growth and survival of metastases depend on interactions between tumor cells and host homeostatic mechanisms. Targeting these interactions, in addition to the tumor cells, can produce synergistic therapeutic effects against existing metastases. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 254 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | <1% |
| United States | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 251 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 56 | 22% |
| Student > Bachelor | 37 | 15% |
| Student > Master | 36 | 14% |
| Researcher | 26 | 10% |
| Student > Doctoral Student | 14 | 6% |
| Other | 30 | 12% |
| Unknown | 55 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 68 | 27% |
| Agricultural and Biological Sciences | 36 | 14% |
| Medicine and Dentistry | 20 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 4% |
| Immunology and Microbiology | 10 | 4% |
| Other | 46 | 18% |
| Unknown | 63 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2016.
All research outputs
#7,115,006
of 23,305,591 outputs
Outputs from Cancer and Metastasis Reviews
#264
of 822 outputs
Outputs of similar age
#82,901
of 268,094 outputs
Outputs of similar age from Cancer and Metastasis Reviews
#5
of 14 outputs
Altmetric has tracked 23,305,591 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 822 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,094 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.