Title |
Cutting-Edge Issues in Celiac Disease and in Gluten Intolerance
|
---|---|
Published in |
Clinical Reviews in Allergy & Immunology, December 2010
|
DOI | 10.1007/s12016-010-8223-1 |
Pubmed ID | |
Authors |
N. Bizzaro, R. Tozzoli, D. Villalta, M. Fabris, E. Tonutti |
Abstract |
Celiac disease (CD) is a gluten-dependent immune-mediated disease with a prevalence in the general population estimated between 0.3% and 1.2%. Large-scale epidemiological studies have shown that only 10-20% of cases of CD are identified on the basis of clinical findings and that laboratory tests are crucial to identify subjects with subtle or atypical symptoms. The correct choice and clinical use of these diagnostic tools may enable accurate diagnosis and early recognition of silent CD cases. In this review, we have considered some relevant aspects related to the laboratory diagnosis of CD and, more extensively, of gluten intolerance, such as the best combination of tests for early and accurate diagnosis, the diagnostic role of new tests for detecting antibodies against neoepitopes produced by the transglutaminase-gliadin complex, the forms of non-celiac gluten intolerance (gluten sensitivity), and the use and significance of measuring cytokines in CD. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
Spain | 1 | 1% |
Italy | 1 | 1% |
Canada | 1 | 1% |
Unknown | 88 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 20 | 22% |
Student > Master | 19 | 20% |
Student > Bachelor | 14 | 15% |
Student > Ph. D. Student | 7 | 8% |
Student > Postgraduate | 6 | 6% |
Other | 15 | 16% |
Unknown | 12 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 25 | 27% |
Medicine and Dentistry | 20 | 22% |
Biochemistry, Genetics and Molecular Biology | 7 | 8% |
Nursing and Health Professions | 5 | 5% |
Immunology and Microbiology | 4 | 4% |
Other | 19 | 20% |
Unknown | 13 | 14% |