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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Epigenomic Co-localization and Co-evolution Reveal a Key Role for 5hmC as a Communication Hub in the Chromatin Network of ESCs
|
|---|---|
| Published in |
Cell Reports, January 2016
|
| DOI | 10.1016/j.celrep.2016.01.008 |
| Pubmed ID | |
| Authors |
David Juan, Juliane Perner, Enrique Carrillo de Santa Pau, Simone Marsili, David Ochoa, Ho-Ryun Chung, Martin Vingron, Daniel Rico, Alfonso Valencia |
| Abstract |
Epigenetic communication through histone and cytosine modifications is essential for gene regulation and cell identity. Here, we propose a framework that is based on a chromatin communication model to get insight on the function of epigenetic modifications in ESCs. The epigenetic communication network was inferred from genome-wide location data plus extensive manual annotation. Notably, we found that 5-hydroxymethylcytosine (5hmC) is the most-influential hub of this network, connecting DNA demethylation to nucleosome remodeling complexes and to key transcription factors of pluripotency. Moreover, an evolutionary analysis revealed a central role of 5hmC in the co-evolution of chromatin-related proteins. Further analysis of regions where 5hmC co-localizes with specific interactors shows that each interaction points to chromatin remodeling, stemness, differentiation, or metabolism. Our results highlight the importance of cytosine modifications in the epigenetic communication of ESCs. |
X Demographics
The data shown below were collected from the profiles of 36 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 19% |
| United Kingdom | 7 | 19% |
| Spain | 4 | 11% |
| Netherlands | 1 | 3% |
| Canada | 1 | 3% |
| Israel | 1 | 3% |
| Venezuela, Bolivarian Republic of | 1 | 3% |
| India | 1 | 3% |
| Hungary | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 11 | 31% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 20 | 56% |
| Scientists | 13 | 36% |
| Science communicators (journalists, bloggers, editors) | 3 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 157 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 1% |
| United States | 2 | 1% |
| Spain | 2 | 1% |
| Sweden | 2 | 1% |
| Italy | 1 | <1% |
| New Caledonia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 146 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 52 | 33% |
| Student > Ph. D. Student | 31 | 20% |
| Student > Master | 15 | 10% |
| Student > Bachelor | 12 | 8% |
| Professor > Associate Professor | 6 | 4% |
| Other | 22 | 14% |
| Unknown | 19 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 64 | 41% |
| Agricultural and Biological Sciences | 56 | 36% |
| Medicine and Dentistry | 4 | 3% |
| Chemistry | 4 | 3% |
| Computer Science | 3 | 2% |
| Other | 4 | 3% |
| Unknown | 22 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 76. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2022.
All research outputs
#561,212
of 25,373,627 outputs
Outputs from Cell Reports
#1,163
of 12,955 outputs
Outputs of similar age
#10,190
of 405,483 outputs
Outputs of similar age from Cell Reports
#25
of 262 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,955 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.3. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 405,483 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 262 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.