| Title |
The effect of resistance training on markers of immune function and inflammation in previously sedentary women recovering from breast cancer: a randomized controlled trial
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, January 2016
|
| DOI | 10.1007/s10549-016-3688-0 |
| Pubmed ID | |
| Authors |
Amanda D. Hagstrom, Paul W. M. Marshall, Chris Lonsdale, Shona Papalia, Birinder S. Cheema, Catherine Toben, Bernhard T. Baune, Maria A. Fiatarone Singh, Simon Green |
| Abstract |
The purpose of this randomized controlled trial was to determine the effects of resistance training (RT) on markers of inflammation and immune function in breast cancer survivors. Thirty-nine breast cancer survivors were randomly assigned to a RT (n = 20) or control (n = 19) group. RT performed supervized exercise three times per week. Natural killer cell (NK) and natural killer T-cell (NKT) function, and markers of inflammation (serum TNF-α, IL-6, IL-10, and CRP) were measured before and after training. Changes in NK and NKT cell function were analyzed using ANCOVA, with the change score the dependent variable, and the baseline value of the same variable the covariate. Effect sizes (ES) were calculated via partial eta-squared. We found a significant reduction, and large associated ESs, in the RT group compared to the control group for change in NK cell expression of TNF-α (p = 0.005, ES = 0.21) and NKT cell expression of TNF-α (p = 0.04, ES = 0.12). No differences were observed in any serum marker. Significant improvements in all measurements of strength were found in RT compared to control (p < 0.001; large ESs ranging from 0.32 to 0.51). These data demonstrate that RT has a beneficial effect on the NK and NKT cell expression of TNF-α indicating that RT may be beneficial in improving the inflammatory profile in breast cancer survivors. |
X Demographics
The data shown below were collected from the profiles of 39 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 6 | 15% |
| United Kingdom | 6 | 15% |
| United States | 4 | 10% |
| Canada | 2 | 5% |
| France | 2 | 5% |
| Norway | 1 | 3% |
| Germany | 1 | 3% |
| Sweden | 1 | 3% |
| Ireland | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 14 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 21 | 54% |
| Scientists | 14 | 36% |
| Practitioners (doctors, other healthcare professionals) | 4 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 258 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | <1% |
| Unknown | 256 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 39 | 15% |
| Student > Bachelor | 31 | 12% |
| Student > Ph. D. Student | 29 | 11% |
| Student > Postgraduate | 26 | 10% |
| Researcher | 22 | 9% |
| Other | 45 | 17% |
| Unknown | 66 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 46 | 18% |
| Sports and Recreations | 46 | 18% |
| Nursing and Health Professions | 34 | 13% |
| Biochemistry, Genetics and Molecular Biology | 14 | 5% |
| Neuroscience | 10 | 4% |
| Other | 27 | 10% |
| Unknown | 81 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2016.
All research outputs
#1,508,313
of 25,245,273 outputs
Outputs from Breast Cancer Research and Treatment
#172
of 4,969 outputs
Outputs of similar age
#26,530
of 408,690 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#2
of 70 outputs
Altmetric has tracked 25,245,273 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,969 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 408,690 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.