| Title |
Lack of microbiological concordance between bone and non-bone specimens in chronic osteomyelitis: an observational study
|
|---|---|
| Published in |
BMC Infectious Diseases, May 2002
|
| DOI | 10.1186/1471-2334-2-8 |
| Pubmed ID | |
| Authors |
Andrés F Zuluaga, Wilson Galvis, Fabián Jaimes, Omar Vesga |
| Abstract |
Prognosis of chronic osteomyelitis depends heavily on proper identification and treatment of the bone-infecting organism. Current knowledge on selecting the best specimen for culture is confusing, and many consider that non-bone specimens are suitable to replace bone cultures. This paper compares the microbiology of non-bone specimens with bone cultures, taking the last as the diagnostic gold standard. Retrospective observational analysis of 50 patients with bacterial chronic osteomyelitis in a 750-bed University-based hospital. Concordance between both specimens for all etiologic agents was 28%, for Staphylococcus aureus 38%, and for organisms other than S. aureus 19%. The culture of non-bone specimens to identify the causative organisms in chronic osteomyelitis produced 52% false negatives and 36% false positives when compared against bone cultures. Diagnosis and therapy of chronic osteomyelitis cannot be guided by cultures of non-bone specimens because their microbiology is substantially different to the microbiology of the bone. |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 2% |
| Colombia | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 55 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 12% |
| Student > Postgraduate | 7 | 12% |
| Professor | 6 | 10% |
| Student > Ph. D. Student | 6 | 10% |
| Student > Doctoral Student | 5 | 9% |
| Other | 13 | 22% |
| Unknown | 14 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 28 | 48% |
| Agricultural and Biological Sciences | 3 | 5% |
| Immunology and Microbiology | 2 | 3% |
| Materials Science | 2 | 3% |
| Business, Management and Accounting | 1 | 2% |
| Other | 4 | 7% |
| Unknown | 18 | 31% |