Title |
Probiotics for treatment and primary prevention of allergic diseases and asthma: looking back and moving forward
|
---|---|
Published in |
Expert Review of Clinical Immunology, March 2016
|
DOI | 10.1586/1744666x.2016.1147955 |
Pubmed ID | |
Authors |
Christina E. West, Maria C. Jenmalm, Anita L. Kozyrskyj, Susan L. Prescott |
Abstract |
Microbial ecosystems cover the surface of the human body and it is becoming increasingly clear that our modern environment has profound effects on microbial composition and diversity. A dysbiotic gut microbiota has been associated with allergic diseases and asthma in cross-sectional and observational studies. In an attempt to restore this dysbiosis, probiotics have been evaluated in randomized controlled trials. Here, we review treatment and primary prevention studies, recent meta-analyses, and discuss the current understanding of the role of probiotics in this context. Many meta-analyses have shown a moderate benefit of probiotics for eczema prevention, whereas there is less evidence of a benefit for other allergic manifestations. Because of very low quality evidence and heterogeneity between studies, specific advice on the most effective regimens cannot yet be given - not even for eczema prevention. To be able to adopt results into specific recommendations, international expert organizations stress the need for well-designed studies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Sweden | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 120 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 23 | 19% |
Researcher | 16 | 13% |
Student > Ph. D. Student | 15 | 13% |
Student > Master | 13 | 11% |
Other | 8 | 7% |
Other | 20 | 17% |
Unknown | 25 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 30 | 25% |
Agricultural and Biological Sciences | 18 | 15% |
Immunology and Microbiology | 12 | 10% |
Biochemistry, Genetics and Molecular Biology | 11 | 9% |
Nursing and Health Professions | 8 | 7% |
Other | 15 | 13% |
Unknown | 26 | 22% |