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Attention Score in Context
| Title |
Natural antisense RNA promotes 3′ end processing and maturation of MALAT1 lncRNA
|
|---|---|
| Published in |
Nucleic Acids Research, January 2016
|
| DOI | 10.1093/nar/gkw047 |
| Pubmed ID | |
| Authors |
Xinying Zong, Shinichi Nakagawa, Susan M. Freier, Jingyi Fei, Taekjip Ha, Supriya G. Prasanth, Kannanganattu V. Prasanth |
| Abstract |
The RNase P-mediated endonucleolytic cleavage plays a crucial role in the 3' end processing and cellular accumulation of MALAT1, a nuclear-retained long noncoding RNA that promotes malignancy. The regulation of this cleavage event is largely undetermined. Here we characterize a broadly expressed natural antisense transcript at the MALAT1 locus, designated as TALAM1, that positively regulates MALAT1 levels by promoting the 3' end cleavage and maturation of MALAT1 RNA. TALAM1 RNA preferentially localizes at the site of transcription, and also interacts with MALAT1 RNA. Depletion of TALAM1 leads to defects in the 3' end cleavage reaction and compromises cellular accumulation of MALAT1. Conversely, overexpression of TALAM1 facilitates the cleavage reaction in trans. Interestingly, TALAM1 is also positively regulated by MALAT1 at the level of both transcription and RNA stability. Together, our data demonstrate a novel feed-forward positive regulatory loop that is established to maintain the high cellular levels of MALAT1, and also unravel the existence of sense-antisense mediated regulatory mechanism for cellular lncRNAs that display RNase P-mediated 3' end processing. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Sao Tome and Principe | 1 | 20% |
| France | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 105 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 24 | 23% |
| Student > Ph. D. Student | 23 | 22% |
| Student > Master | 13 | 12% |
| Student > Bachelor | 11 | 10% |
| Other | 7 | 7% |
| Other | 14 | 13% |
| Unknown | 13 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 45 | 43% |
| Agricultural and Biological Sciences | 25 | 24% |
| Medicine and Dentistry | 5 | 5% |
| Chemistry | 4 | 4% |
| Neuroscience | 4 | 4% |
| Other | 6 | 6% |
| Unknown | 16 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2023.
All research outputs
#15,367,630
of 25,692,343 outputs
Outputs from Nucleic Acids Research
#21,923
of 27,687 outputs
Outputs of similar age
#207,756
of 406,962 outputs
Outputs of similar age from Nucleic Acids Research
#160
of 260 outputs
Altmetric has tracked 25,692,343 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 27,687 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 406,962 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 260 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.