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HLA class II sequence variants influence tuberculosis risk in populations of European ancestry

Overview of attention for article published in Nature Genetics, February 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)

Mentioned by

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1 news outlet
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13 X users
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2 Facebook pages

Citations

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120 Dimensions

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163 Mendeley
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4 CiteULike
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Title
HLA class II sequence variants influence tuberculosis risk in populations of European ancestry
Published in
Nature Genetics, February 2016
DOI 10.1038/ng.3498
Pubmed ID
Authors

Gardar Sveinbjornsson, Daniel F Gudbjartsson, Bjarni V Halldorsson, Karl G Kristinsson, Magnus Gottfredsson, Jeffrey C Barrett, Larus J Gudmundsson, Kai Blondal, Arnaldur Gylfason, Sigurjon Axel Gudjonsson, Hafdis T Helgadottir, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Ari Karason, Ljiljana Bulat Kardum, Jelena Knežević, Helgi Kristjansson, Mar Kristjansson, Arthur Love, Yang Luo, Olafur T Magnusson, Patrick Sulem, Augustine Kong, Gisli Masson, Unnur Thorsteinsdottir, Zlatko Dembic, Sergey Nejentsev, Thorsteinn Blondal, Ingileif Jonsdottir, Kari Stefansson

Abstract

Mycobacterium tuberculosis infections cause 9 million new tuberculosis cases and 1.5 million deaths annually. To identify variants conferring risk of tuberculosis, we tested 28.3 million variants identified through whole-genome sequencing of 2,636 Icelanders for association with tuberculosis (8,162 cases and 277,643 controls), pulmonary tuberculosis (PTB) and M. tuberculosis infection. We found association of three variants in the region harboring genes encoding the class II human leukocyte antigens (HLAs): rs557011[T] (minor allele frequency (MAF) = 40.2%), associated with M. tuberculosis infection (odds ratio (OR) = 1.14, P = 3.1 × 10(-13)) and PTB (OR = 1.25, P = 5.8 × 10(-12)), and rs9271378[G] (MAF = 32.5%), associated with PTB (OR = 0.78, P = 2.5 × 10(-12))-both located between HLA-DQA1 and HLA-DRB1-and a missense variant encoding p.Ala210Thr in HLA-DQA1 (MAF = 19.1%, rs9272785), associated with M. tuberculosis infection (P = 9.3 × 10(-9), OR = 1.14). We replicated association of these variants with PTB in samples of European ancestry from Russia and Croatia (P < 5.9 × 10(-4)). These findings show that the HLA class II region contributes to genetic risk of tuberculosis, possibly through reduced presentation of protective M. tuberculosis antigens to T cells.

X Demographics

X Demographics

The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 163 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 1%
Netherlands 1 <1%
Korea, Republic of 1 <1%
Brazil 1 <1%
Germany 1 <1%
South Africa 1 <1%
Sweden 1 <1%
Thailand 1 <1%
United States 1 <1%
Other 0 0%
Unknown 153 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 33 20%
Student > Ph. D. Student 27 17%
Student > Bachelor 21 13%
Student > Master 19 12%
Student > Doctoral Student 9 6%
Other 30 18%
Unknown 24 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 41 25%
Agricultural and Biological Sciences 26 16%
Medicine and Dentistry 22 13%
Immunology and Microbiology 14 9%
Nursing and Health Professions 6 4%
Other 21 13%
Unknown 33 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2024.
All research outputs
#1,837,073
of 25,171,741 outputs
Outputs from Nature Genetics
#2,530
of 7,543 outputs
Outputs of similar age
#32,079
of 409,322 outputs
Outputs of similar age from Nature Genetics
#47
of 63 outputs
Altmetric has tracked 25,171,741 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,543 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.0. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 409,322 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.