| Title |
Regulatory T cells ameliorate cardiac remodeling after myocardial infarction
|
|---|---|
| Published in |
Basic Research in Cardiology, December 2011
|
| DOI | 10.1007/s00395-011-0232-6 |
| Pubmed ID | |
| Authors |
Ting-Ting Tang, Jing Yuan, Zheng-Feng Zhu, Wen-Cai Zhang, Hong Xiao, Ni Xia, Xin-Xin Yan, Shao-Fang Nie, Juan Liu, Su-Feng Zhou, Jing-Jing Li, Rui Yao, Meng-Yang Liao, Xin Tu, Yu-Hua Liao, Xiang Cheng |
| Abstract |
Persistent inflammatory responses participate in the pathogenesis of adverse ventricular remodeling after myocardial infarction (MI). We hypothesized that regulatory T (Treg) cells modulate inflammatory responses, attenuate ventricular remodeling and subsequently improve cardiac function after MI. Acute MI was induced by ligation of the left anterior descending coronary artery in rats. Infiltration of Foxp3(+) Treg cells was detected in the infarcted heart. Expansion of Treg cells in vivo by means of adoptive transfer as well as a CD28 superagonistic antibody (JJ316) resulted in an increased number of Foxp3(+) Treg cells in the infarcted heart. Subsequently, rats with MI showed improved cardiac function following Treg cells transfer or JJ316 injection. Interstitial fibrosis, myocardial matrix metalloproteinase-2 activity and cardiac apoptosis were attenuated in the rats that received Treg cells transfer. Infiltration of neutrophils, macrophages and lymphocytes as well as expression of tumor necrosis factor (TNF)-α and interleukin (IL)-1β were also significantly decreased, and the CD8(+) cardiac-specific cytotoxic T lymphocyte response was inhibited. Expression of interleukin (IL)-10 in the heart, however, was increased. Additional studies in vitro indicated that Treg cells directly protect neonatal rat cardiomyocytes against LPS-induced apoptosis, and this protection depends on the cell-cell contact and IL-10 expression. Furthermore, Treg cells inhibited proinflammatory cytokines production by cardiomyocytes. These data demonstrate that Treg cells serve to protect against adverse ventricular remodeling and contribute to improve cardiac function after myocardial infarction via inhibition of inflammation and direct protection of cardiomyocytes. |
Mendeley readers
The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 146 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 23% |
| Researcher | 18 | 12% |
| Student > Bachelor | 18 | 12% |
| Student > Doctoral Student | 15 | 10% |
| Student > Master | 12 | 8% |
| Other | 21 | 14% |
| Unknown | 30 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 46 | 31% |
| Biochemistry, Genetics and Molecular Biology | 25 | 17% |
| Agricultural and Biological Sciences | 23 | 16% |
| Immunology and Microbiology | 7 | 5% |
| Engineering | 3 | 2% |
| Other | 8 | 5% |
| Unknown | 36 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2022.
All research outputs
#7,411,964
of 22,660,862 outputs
Outputs from Basic Research in Cardiology
#180
of 643 outputs
Outputs of similar age
#70,483
of 243,133 outputs
Outputs of similar age from Basic Research in Cardiology
#2
of 6 outputs
Altmetric has tracked 22,660,862 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 643 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,133 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.