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Resveratrol analogue 4,4′-dihydroxy-trans-stilbene potently inhibits cancer invasion and metastasis

Overview of attention for article published in Scientific Reports, February 2016
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Title
Resveratrol analogue 4,4′-dihydroxy-trans-stilbene potently inhibits cancer invasion and metastasis
Published in
Scientific Reports, February 2016
DOI 10.1038/srep19973
Pubmed ID
Authors

Monica Savio, Daniela Ferraro, Cristina Maccario, Rita Vaccarone, Lasse D. Jensen, Federica Corana, Barbara Mannucci, Livia Bianchi, Yihai Cao, Lucia Anna Stivala

Abstract

We investigated the preventive effects of resveratrol analogue 4,4'-dihydroxy-trans-stilbene (DHS) on cancer invasion and metastasis. Two different in vivo approaches of mouse and zebrafish lung cancer invasion models were employed in our study. The in vitro results showed that DHS displays potent inhibition on anchorage-dependent or -independent cell growth of LLC cells, leading to impairment of the cell cycle progression with reduction of cell numbers arresting at the G1 phase, an evident accumulation of pre-G1 events correlated with apoptotic behaviour. In addition, DHS induces a marked inhibition of LLC cell migration and matrigel invasion. In a murine lung cancer model, tumour volume, cell proliferation, and tumour angiogenesis were significantly inhibited by DHS. Importantly, liver metastatic lesions were significantly reduced in DHS-treated mice. Similarly, DHS significantly inhibits lung cancer cell dissemination, invasion and metastasis in a zebrafish tumour model. These findings demonstrate that DHS could potentially be developed as a novel therapeutic agent for treatment of cancer and metastasis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 23%
Researcher 7 13%
Student > Bachelor 6 12%
Student > Master 5 10%
Student > Doctoral Student 3 6%
Other 10 19%
Unknown 9 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 15 29%
Chemistry 7 13%
Agricultural and Biological Sciences 7 13%
Medicine and Dentistry 6 12%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 4 8%
Unknown 12 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2016.
All research outputs
#18,345,259
of 23,577,654 outputs
Outputs from Scientific Reports
#90,655
of 127,511 outputs
Outputs of similar age
#274,678
of 400,437 outputs
Outputs of similar age from Scientific Reports
#2,331
of 3,219 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 127,511 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.4. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 400,437 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3,219 others from the same source and published within six weeks on either side of this one. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.