| Title |
Fornix deep brain stimulation induced long-term spatial memory independent of hippocampal neurogenesis
|
|---|---|
| Published in |
Brain Structure and Function, February 2016
|
| DOI | 10.1007/s00429-016-1188-y |
| Pubmed ID | |
| Authors |
Sarah Hescham, Yasin Temel, Sandra Schipper, Mélanie Lagiere, Lisa-Maria Schönfeld, Arjan Blokland, Ali Jahanshahi |
| Abstract |
Deep brain stimulation (DBS) is an established symptomatic treatment modality for movement disorders and constitutes an emerging therapeutic approach for the treatment of memory impairment. In line with this, fornix DBS has shown to ameliorate cognitive decline associated with dementia. Nonetheless, mechanisms mediating clinical effects in demented patients or patients with other neurological disorders are largely unknown. There is evidence that DBS is able to modulate neurophysiological activity in targeted brain regions. We therefore hypothesized that DBS might be able to influence cognitive function via activity-dependent regulation of hippocampal neurogenesis. Using stimulation parameters, which were validated to restore memory loss in a previous behavioral study, we here assessed long-term effects of fornix DBS. To do so, we injected the thymidine analog, 5-bromo-2'-deoxyuridine (BrdU), after DBS and perfused the animals 6.5 weeks later. A week prior to perfusion, memory performance was assessed in the water maze. We found that acute stimulation of the fornix improved spatial memory performance in the water maze when the probe trial was performed 1 h after the last training session. However, no evidence for stimulation-induced neurogenesis was found in fornix DBS rats when compared to sham. Our results suggest that fornix DBS improves memory functions independent of hippocampal neurogenesis, possibly through other mechanisms such as synaptic plasticity and acute neurotransmitter release. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 2% |
| Unknown | 58 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 17% |
| Researcher | 9 | 15% |
| Student > Ph. D. Student | 6 | 10% |
| Student > Master | 6 | 10% |
| Other | 5 | 8% |
| Other | 12 | 20% |
| Unknown | 11 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 19 | 32% |
| Biochemistry, Genetics and Molecular Biology | 5 | 8% |
| Psychology | 5 | 8% |
| Agricultural and Biological Sciences | 5 | 8% |
| Medicine and Dentistry | 4 | 7% |
| Other | 7 | 12% |
| Unknown | 14 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2017.
All research outputs
#19,015,393
of 24,217,893 outputs
Outputs from Brain Structure and Function
#1,150
of 1,725 outputs
Outputs of similar age
#280,000
of 405,667 outputs
Outputs of similar age from Brain Structure and Function
#22
of 34 outputs
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