| Title |
Novel Controlled Release Polymer-Lipid Formulations Processed by Hot Melt Extrusion
|
|---|---|
| Published in |
AAPS PharmSciTech, December 2015
|
| DOI | 10.1208/s12249-015-0470-2 |
| Pubmed ID | |
| Authors |
Mohammed Maniruzzaman, Muhammad T. Islam, Sheelagh Halsey, Devyani Amin, Dennis Douroumis |
| Abstract |
The aim of the study was to investigate the effect of novel polymer/lipid formulations on the dissolution rates of the water insoluble indomethacin (INM), co-processed by hot melt extrusion (HME). Formulations consisted of the hydrophilic hydroxypropyl methyl cellulose polymer (HPMCAS) and stearoyl macrogol-32 glycerides-Gelucire 50/13 (GLC) were processed with a twin screw extruder to produce solid dispersions. The extrudates characterized by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and hot stage microscopy (HSM) indicated the presence of amorphous INM within the polymer/lipid matrices. In-line monitoring via near-infrared (NIR) spectroscopy revealed significant peak shifts indicating possible interactions and H-bonding formation between the drug and the polymer/lipid carriers. Furthermore, in vitro dissolution studies showed a synergistic effect of the polymer/lipid carrier with 2-h lag time in acidic media followed by enhanced INM dissolution rates at pH > 5.5. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 41 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 22% |
| Other | 4 | 10% |
| Researcher | 4 | 10% |
| Student > Master | 4 | 10% |
| Professor | 3 | 7% |
| Other | 6 | 15% |
| Unknown | 11 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 16 | 39% |
| Medicine and Dentistry | 4 | 10% |
| Chemistry | 4 | 10% |
| Social Sciences | 2 | 5% |
| Agricultural and Biological Sciences | 2 | 5% |
| Other | 2 | 5% |
| Unknown | 11 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 February 2016.
All research outputs
#18,437,241
of 22,842,950 outputs
Outputs from AAPS PharmSciTech
#1,222
of 1,468 outputs
Outputs of similar age
#281,144
of 389,430 outputs
Outputs of similar age from AAPS PharmSciTech
#25
of 30 outputs
Altmetric has tracked 22,842,950 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,468 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 389,430 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.