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How can cognitive remediation therapy modulate brain activations in schizophrenia? An fMRI study

Overview of attention for article published in Psychiatry Research, May 2011
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Title
How can cognitive remediation therapy modulate brain activations in schizophrenia? An fMRI study
Published in
Psychiatry Research, May 2011
DOI 10.1016/j.pscychresns.2010.12.004
Pubmed ID
Authors

Julie Bor, Jérôme Brunelin, Thierry d'Amato, Nicolas Costes, Marie-Françoise Suaud-Chagny, Mohamed Saoud, Emmanuel Poulet

Abstract

Cognitive remediation therapy (CRT) is a non biological treatment that aims to correct cognitive deficits through repeated exercises. Its efficacy in patients with schizophrenia is well recognized, but little is known about its effect on cerebral activity. Our aim was to explore the impact of CRT on cerebral activation using functional magnetic resonance imaging (fMRI) in patients with schizophrenia. Seventeen patients and 15 healthy volunteers were recruited. Patients were divided into two groups: one group received CRT with Rehacom® software (n=8), while a control group of patients (non-CRT group) received no additional treatment (n=9). The three groups underwent two fMRI sessions with an interval of 3months: they had to perform a verbal and a spatial n-back task at the same performance level. Patients were additionally clinically and cognitively assessed before and after the study. After CRT, the CRT group exhibited brain over-activations in the left inferior/middle frontal gyrus, cingulate gyrus and inferior parietal lobule for the spatial task. Similar but nonsignificant over-activations were observed in the same brain regions for the verbal task. Moreover, CRT patients significantly improved their behavioural performance in attention and reasoning capacities. We conclude that CRT leads to measurable physiological adaptation associated with improved cognitive ability. Trial name: Cognitive Remediation Theraphy and Schizophrenia. http://clinicaltrials.gov/ct2/show/NCT01078129. Registration number: NCT01078129.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 205 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Australia 1 <1%
Canada 1 <1%
Mexico 1 <1%
Argentina 1 <1%
Spain 1 <1%
Japan 1 <1%
Unknown 198 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 32 16%
Student > Master 32 16%
Researcher 30 15%
Student > Bachelor 23 11%
Student > Doctoral Student 14 7%
Other 41 20%
Unknown 33 16%
Readers by discipline Count As %
Psychology 82 40%
Medicine and Dentistry 35 17%
Neuroscience 16 8%
Agricultural and Biological Sciences 12 6%
Pharmacology, Toxicology and Pharmaceutical Science 3 1%
Other 12 6%
Unknown 45 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 December 2011.
All research outputs
#17,283,763
of 25,371,288 outputs
Outputs from Psychiatry Research
#4,805
of 7,587 outputs
Outputs of similar age
#94,353
of 121,636 outputs
Outputs of similar age from Psychiatry Research
#38
of 57 outputs
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