Title |
Biomaterial‐Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives
|
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Published in |
Advanced Materials, February 2016
|
DOI | 10.1002/adma.201505349 |
Pubmed ID | |
Authors |
Hugh S O'Neill, Laura B Gallagher, Janice O'Sullivan, William Whyte, Clive Curley, Eimear Dolan, Aamir Hameed, Joanne O'Dwyer, Christina Payne, Daniel O'Reilly, Eduardo Ruiz-Hernandez, Ellen T Roche, Fergal J O'Brien, Sally Ann Cryan, Helena Kelly, Bruce Murphy, Garry P Duffy |
Abstract |
Heart failure is a significant clinical issue. It is the cause of enormous healthcare costs worldwide and results in significant morbidity and mortality. Cardiac regenerative therapy has progressed considerably from clinical and preclinical studies delivering simple suspensions of cells, macromolecule, and small molecules to more advanced delivery methods utilizing biomaterial scaffolds as depots for localized targeted delivery to the damaged and ischemic myocardium. Here, regenerative strategies for cardiac tissue engineering with a focus on advanced delivery strategies and the use of multimodal therapeutic strategies are reviewed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Ireland | 7 | 58% |
United States | 2 | 17% |
Portugal | 1 | 8% |
Spain | 1 | 8% |
Unknown | 1 | 8% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 50% |
Scientists | 5 | 42% |
Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
Australia | 2 | 2% |
Poland | 1 | <1% |
Unknown | 119 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 30 | 24% |
Researcher | 15 | 12% |
Student > Bachelor | 12 | 10% |
Student > Master | 11 | 9% |
Professor | 6 | 5% |
Other | 21 | 17% |
Unknown | 29 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 24 | 19% |
Chemistry | 13 | 10% |
Medicine and Dentistry | 13 | 10% |
Materials Science | 12 | 10% |
Biochemistry, Genetics and Molecular Biology | 11 | 9% |
Other | 14 | 11% |
Unknown | 37 | 30% |