| Title |
Human kidney proximal tubule cells are vulnerable to the effects of Rauwolfia serpentina
|
|---|---|
| Published in |
Cell Biology and Toxicology, February 2016
|
| DOI | 10.1007/s10565-016-9311-7 |
| Pubmed ID | |
| Authors |
Miriam E. Mossoba, Thomas J. Flynn, Sanah Vohra, Paddy L. Wiesenfeld, Robert L. Sprando |
| Abstract |
Rauwolfia serpentina (or Snake root plant) is a botanical dietary supplement marketed in the USA for maintaining blood pressure. Very few studies have addressed the safety of this herb, despite its wide availability to consumers. Its reported pleiotropic effects underscore the necessity for evaluating its safety. We used a human kidney cell line to investigate the possible negative effects of R. serpentina on the renal system in vitro, with a specific focus on the renal proximal tubules. We evaluated cellular and mitochondrial toxicity, along with a variety of other kidney-specific toxicology biomarkers. We found that R. serpentina was capable of producing highly detrimental effects in our in vitro renal cell system. These results suggest more studies are needed to investigate the safety of this dietary supplement in both kidney and other target organ systems. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 3 | 43% |
| Germany | 1 | 14% |
| United Kingdom | 1 | 14% |
| Unknown | 2 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 21% |
| Student > Master | 2 | 11% |
| Student > Bachelor | 2 | 11% |
| Unspecified | 1 | 5% |
| Librarian | 1 | 5% |
| Other | 2 | 11% |
| Unknown | 7 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 11% |
| Biochemistry, Genetics and Molecular Biology | 2 | 11% |
| Unspecified | 1 | 5% |
| Arts and Humanities | 1 | 5% |
| Business, Management and Accounting | 1 | 5% |
| Other | 3 | 16% |
| Unknown | 9 | 47% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2021.
All research outputs
#7,344,654
of 25,789,020 outputs
Outputs from Cell Biology and Toxicology
#101
of 530 outputs
Outputs of similar age
#109,528
of 408,278 outputs
Outputs of similar age from Cell Biology and Toxicology
#1
of 4 outputs
Altmetric has tracked 25,789,020 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 530 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 80% of its peers.
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We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them