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Copeptin Levels Do Not Correlate With Cross-Clamping Time in Patients Undergoing Carotid Endarterectomy Under General Anesthesia

Overview of attention for article published in Angiology, July 2016
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Title
Copeptin Levels Do Not Correlate With Cross-Clamping Time in Patients Undergoing Carotid Endarterectomy Under General Anesthesia
Published in
Angiology, July 2016
DOI 10.1177/0003319716629322
Pubmed ID
Authors

Dragana Unic-Stojanovic, Esma R. Isenovic, Miomir Jovic, Vera Maravic-Stojkovic, Milica Miljkovic, Tamara Gojkovic, Biljana Milicic, Nikola Bogdanovic, Djordje Radak

Abstract

Copeptin is a sensitive and more stable surrogate marker for arginine vasopressin. In this study, we evaluated copeptin levels in carotid endarterectomy (CEA) patients, perioperatively, to determine whether copeptin levels can be related to carotid artery cross clamping (CC) time and to postoperative neurological outcomes. Copeptin, interleukin 6, C-reactive protein, cortisol, and brain natriuretic peptide were measured preoperatively (T1) and 3 hours postoperatively (T3) as well as intraoperatively (T2). We recruited 77 patients. Values of copeptin rose gradually over the observed times: T1 = 7.9 (6.4-9.6), T2 = 12.6 (9.3-16.8), and T3 = 72.3 (49.1-111.2) pmol/L. There was a significant difference for repeated measurement (P = .000, P = .000, and P = .000). Duration of carotid artery CC during CEA does not affect postoperative copeptin level (CC ≤ 13 minutes: 106.8 ± 93.6 pmol/L, CC > 13 minutes: 96.7 ± 89.1 pmol/L; P = .634). Preoperative copeptin level was significantly higher in patients with ulcerated plaque morphology. Activation of the stress axis in patients undergoing CEA results in copeptin elevation. Duration of CC during CEA does not affect postoperative copeptin levels.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 19%
Student > Ph. D. Student 3 19%
Student > Doctoral Student 2 13%
Librarian 1 6%
Professor 1 6%
Other 3 19%
Unknown 3 19%
Readers by discipline Count As %
Medicine and Dentistry 5 31%
Biochemistry, Genetics and Molecular Biology 2 13%
Immunology and Microbiology 1 6%
Arts and Humanities 1 6%
Sports and Recreations 1 6%
Other 1 6%
Unknown 5 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2016.
All research outputs
#20,303,950
of 22,842,950 outputs
Outputs from Angiology
#716
of 839 outputs
Outputs of similar age
#308,098
of 354,190 outputs
Outputs of similar age from Angiology
#329
of 351 outputs
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We're also able to compare this research output to 351 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.