| Title |
Broadly Neutralizing Antibodies for HIV Eradication
|
|---|---|
| Published in |
Current HIV/AIDS Reports, February 2016
|
| DOI | 10.1007/s11904-016-0299-7 |
| Pubmed ID | |
| Authors |
Kathryn E. Stephenson, Dan H. Barouch |
| Abstract |
Passive transfer of antibodies has long been considered a potential treatment modality for infectious diseases, including HIV. Early efforts to use antibodies to suppress HIV replication, however, were largely unsuccessful, as the antibodies that were studied neutralized only a relatively narrow spectrum of viral strains and were not very potent. Recent advances have led to the discovery of a large portfolio of human monoclonal antibodies that are broadly neutralizing across many HIV-1 subtypes and are also substantially more potent. These antibodies target multiple different epitopes on the HIV envelope, thus allowing for the development of antibody combinations. In this review, we discuss the application of broadly neutralizing antibodies (bNAbs) for HIV treatment and HIV eradication strategies. We highlight bNAbs that target key epitopes, such as the CD4 binding site and the V2/V3-glycan-dependent sites, and we discuss several bNAbs that are currently in the clinical development pipeline. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 67% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 50% |
| Members of the public | 3 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 127 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 23% |
| Student > Bachelor | 20 | 16% |
| Researcher | 16 | 12% |
| Student > Master | 11 | 9% |
| Student > Doctoral Student | 7 | 5% |
| Other | 21 | 16% |
| Unknown | 24 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 29 | 22% |
| Agricultural and Biological Sciences | 29 | 22% |
| Medicine and Dentistry | 18 | 14% |
| Immunology and Microbiology | 17 | 13% |
| Engineering | 3 | 2% |
| Other | 9 | 7% |
| Unknown | 24 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2024.
All research outputs
#1,728,480
of 23,592,647 outputs
Outputs from Current HIV/AIDS Reports
#30
of 435 outputs
Outputs of similar age
#32,112
of 400,036 outputs
Outputs of similar age from Current HIV/AIDS Reports
#1
of 9 outputs
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