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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Broadly Neutralizing Antibodies Against HIV: New Insights to Inform Vaccine Design
|
|---|---|
| Published in |
Annual Review of Medicine, November 2015
|
| DOI | 10.1146/annurev-med-091014-090749 |
| Pubmed ID | |
| Authors |
Saheli Sadanand, Todd J Suscovich, Galit Alter |
| Abstract |
HIV-1 poses immense immunological challenges to the humoral immune response because of its ability to shield itself and replicate and evolve rapidly. Although most currently licensed vaccines provide protection via the induction of antibodies (Abs) that can directly block infection (1), 30 years of HIV-1 vaccine research has failed to successfully elicit such Abs against globally relevant HIV strains. However, mounting evidence suggests that these broadly neutralizing antibodies (bNAbs) do emerge naturally in a significant fraction of infected subjects, albeit after years of infection, indicating that these responses can be selected naturally by the immune response but take long periods of time to evolve. We review the basic structural characteristics of broadly neutralizing antibodies and how they recognize the virus, and we discuss new vaccination strategies that aim to mimic natural evolution to guide B cells to produce protective Abs against HIV-1. Expected final online publication date for the Annual Review of Medicine Volume 67 is January 14, 2016. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Kenya | 1 | 50% |
| Canada | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 1% |
| Sweden | 1 | 1% |
| South Africa | 1 | 1% |
| United Kingdom | 1 | 1% |
| Peru | 1 | 1% |
| Puerto Rico | 1 | 1% |
| Unknown | 86 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 22% |
| Researcher | 16 | 17% |
| Student > Bachelor | 14 | 15% |
| Student > Master | 11 | 12% |
| Other | 5 | 5% |
| Other | 10 | 11% |
| Unknown | 16 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 22% |
| Immunology and Microbiology | 19 | 21% |
| Agricultural and Biological Sciences | 18 | 20% |
| Medicine and Dentistry | 13 | 14% |
| Environmental Science | 1 | 1% |
| Other | 6 | 7% |
| Unknown | 15 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2021.
All research outputs
#1,233,441
of 25,374,917 outputs
Outputs from Annual Review of Medicine
#68
of 905 outputs
Outputs of similar age
#18,288
of 297,467 outputs
Outputs of similar age from Annual Review of Medicine
#2
of 12 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 905 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.4. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,467 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.