Title |
Use of inhaled corticosteroids in COPD: improving efficacy
|
---|---|
Published in |
Expert Review of Respiratory Medicine, February 2016
|
DOI | 10.1586/17476348.2016.1151789 |
Pubmed ID | |
Authors |
Ian A. Yang, Janet G. Shaw, John R. Goddard, Melissa S. Clarke, David W. Reid |
Abstract |
Chronic obstructive pulmonary disease (COPD) is a chronic, inflammatory lung disease characterized by airflow limitation that is not fully reversible. The pathological changes in COPD lead to alveolar destruction (emphysema) and chronic airway inflammation, resulting in airflow obstruction and recurrent exacerbations. Inhaled corticosteroids (ICS) are anti-inflammatory agents that are widely used, especially in combination with long-acting beta-agonists, in patients with COPD. Here, we will summarize the benefits and risks of ICS use for COPD, and discuss approaches to more personalized medicine when selecting COPD patients to commence (or withdraw) ICS use. The conclusion arising is that further validation of clinical and biological markers should be undertaken in COPD, in order to individualize ICS therapy to maximize efficacy for patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Unknown | 59 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 13 | 22% |
Student > Master | 10 | 17% |
Student > Ph. D. Student | 6 | 10% |
Researcher | 4 | 7% |
Student > Postgraduate | 4 | 7% |
Other | 9 | 15% |
Unknown | 14 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 27% |
Biochemistry, Genetics and Molecular Biology | 7 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
Immunology and Microbiology | 4 | 7% |
Nursing and Health Professions | 3 | 5% |
Other | 9 | 15% |
Unknown | 16 | 27% |