| Title |
HIV/HCV Co-infection: Pathogenesis, Clinical Complications, Treatment, and New Therapeutic Technologies
|
|---|---|
| Published in |
Current HIV/AIDS Reports, January 2011
|
| DOI | 10.1007/s11904-010-0071-3 |
| Pubmed ID | |
| Authors |
Eva A. Operskalski, Andrea Kovacs |
| Abstract |
World-wide, hepatitis C virus (HCV) accounts for approximately 130 million chronic infections, with an overall 3% prevalence. Four to 5 million persons are co-infected with HIV. It is well established that HIV has a negative impact on the natural history of HCV, including a higher rate of viral persistence, increased viral load, and more rapid progression to fibrosis, end-stage liver disease, and death. Whether HCV has a negative impact on HIV disease progression continues to be debated. However, following the introduction of effective combination antiretroviral therapy, the survival of coinfected individuals has significantly improved and HCV-associated diseases have emerged as the most important co-morbidities. In this review, we summarize the newest studies regarding the pathogenesis of HIV/HCV coinfection, including effects of coinfection on HIV disease progression, HCV-associated liver disease, the immune system, kidney and cardiovascular disease, and neurologic status; and effectiveness of current anti-HIV and HCV therapies and proposed new treatment strategies. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 234 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| Italy | 1 | <1% |
| Vietnam | 1 | <1% |
| Brazil | 1 | <1% |
| Canada | 1 | <1% |
| United States | 1 | <1% |
| Serbia | 1 | <1% |
| Unknown | 226 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 38 | 16% |
| Researcher | 36 | 15% |
| Student > Bachelor | 36 | 15% |
| Student > Ph. D. Student | 25 | 11% |
| Student > Postgraduate | 18 | 8% |
| Other | 47 | 20% |
| Unknown | 34 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 91 | 39% |
| Agricultural and Biological Sciences | 32 | 14% |
| Biochemistry, Genetics and Molecular Biology | 16 | 7% |
| Immunology and Microbiology | 9 | 4% |
| Nursing and Health Professions | 8 | 3% |
| Other | 35 | 15% |
| Unknown | 43 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2018.
All research outputs
#7,358,432
of 23,926,844 outputs
Outputs from Current HIV/AIDS Reports
#189
of 443 outputs
Outputs of similar age
#52,960
of 186,380 outputs
Outputs of similar age from Current HIV/AIDS Reports
#3
of 5 outputs
Altmetric has tracked 23,926,844 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 443 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 186,380 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.