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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genome Variation in Cryptococcus gattii, an Emerging Pathogen of Immunocompetent Hosts
|
|---|---|
| Published in |
mBio, February 2011
|
| DOI | 10.1128/mbio.00342-10 |
| Pubmed ID | |
| Authors |
C. A. D’Souza, J. W. Kronstad, G. Taylor, R. Warren, M. Yuen, G. Hu, W. H. Jung, A. Sham, S. E. Kidd, K. Tangen, N. Lee, T. Zeilmaker, J. Sawkins, G. McVicker, S. Shah, S. Gnerre, A. Griggs, Q. Zeng, K. Bartlett, W. Li, X. Wang, J. Heitman, J. E. Stajich, J. A. Fraser, W. Meyer, D. Carter, J. Schein, M. Krzywinski, K. J. Kwon-Chung, A. Varma, J. Wang, R. Brunham, M. Fyfe, B. F. F. Ouellette, A. Siddiqui, M. Marra, S. Jones, R. Holt, B. W. Birren, J. E. Galagan, C. A. Cuomo |
| Abstract |
Cryptococcus gattii recently emerged as the causative agent of cryptococcosis in healthy individuals in western North America, despite previous characterization of the fungus as a pathogen in tropical or subtropical regions. As a foundation to study the genetics of virulence in this pathogen, we sequenced the genomes of a strain (WM276) representing the predominant global molecular type (VGI) and a clinical strain (R265) of the major genotype (VGIIa) causing disease in North America. We compared these C. gattii genomes with each other and with the genomes of representative strains of the two varieties of Cryptococcus neoformans that generally cause disease in immunocompromised people. Our comparisons included chromosome alignments, analysis of gene content and gene family evolution, and comparative genome hybridization (CGH). These studies revealed that the genomes of the two representative C. gattii strains (genotypes VGI and VGIIa) are colinear for the majority of chromosomes, with some minor rearrangements. However, multiortholog phylogenetic analysis and an evaluation of gene/sequence conservation support the existence of speciation within the C. gattii complex. More extensive chromosome rearrangements were observed upon comparison of the C. gattii and the C. neoformans genomes. Finally, CGH revealed considerable variation in clinical and environmental isolates as well as changes in chromosome copy numbers in C. gattii isolates displaying fluconazole heteroresistance. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 137 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Netherlands | 1 | <1% |
| Colombia | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 131 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 18% |
| Researcher | 21 | 15% |
| Student > Master | 14 | 10% |
| Student > Bachelor | 14 | 10% |
| Professor | 12 | 9% |
| Other | 29 | 21% |
| Unknown | 22 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 51 | 37% |
| Biochemistry, Genetics and Molecular Biology | 25 | 18% |
| Medicine and Dentistry | 13 | 9% |
| Immunology and Microbiology | 10 | 7% |
| Chemistry | 2 | 1% |
| Other | 7 | 5% |
| Unknown | 29 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2022.
All research outputs
#3,274,360
of 25,373,627 outputs
Outputs from mBio
#2,467
of 6,507 outputs
Outputs of similar age
#19,300
of 194,704 outputs
Outputs of similar age from mBio
#10
of 18 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,507 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.0. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,704 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.