Title |
IFI16 is an innate immune sensor for intracellular DNA
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Published in |
Nature Immunology, October 2010
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DOI | 10.1038/ni.1932 |
Pubmed ID | |
Authors |
Leonie Unterholzner, Sinead E Keating, Marcin Baran, Kristy A Horan, Søren B Jensen, Shruti Sharma, Cherilyn M Sirois, Tengchuan Jin, Eicke Latz, T Sam Xiao, Katherine A Fitzgerald, Søren R Paludan, Andrew G Bowie |
Abstract |
The detection of intracellular microbial DNA is critical to appropriate innate immune responses; however, knowledge of how such DNA is sensed is limited. Here we identify IFI16, a PYHIN protein, as an intracellular DNA sensor that mediates the induction of interferon-β (IFN-β). IFI16 directly associated with IFN-β-inducing viral DNA motifs. STING, a critical mediator of IFN-β responses to DNA, was recruited to IFI16 after DNA stimulation. Lowering the expression of IFI16 or its mouse ortholog p204 by RNA-mediated interference inhibited gene induction and activation of the transcription factors IRF3 and NF-κB induced by DNA and herpes simplex virus type 1 (HSV-1). IFI16 (p204) is the first PYHIN protein to our knowledge shown to be involved in IFN-β induction. Thus, the PYHIN proteins IFI16 and AIM2 form a new family of innate DNA sensors we call 'AIM2-like receptors' (ALRs). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Ireland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 12 | 1% |
France | 5 | <1% |
Germany | 3 | <1% |
Japan | 3 | <1% |
United Kingdom | 3 | <1% |
Netherlands | 2 | <1% |
Austria | 1 | <1% |
Brazil | 1 | <1% |
Italy | 1 | <1% |
Other | 7 | <1% |
Unknown | 842 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 253 | 29% |
Researcher | 135 | 15% |
Student > Bachelor | 117 | 13% |
Student > Master | 87 | 10% |
Student > Doctoral Student | 41 | 5% |
Other | 124 | 14% |
Unknown | 123 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 322 | 37% |
Biochemistry, Genetics and Molecular Biology | 154 | 18% |
Immunology and Microbiology | 117 | 13% |
Medicine and Dentistry | 84 | 10% |
Neuroscience | 15 | 2% |
Other | 54 | 6% |
Unknown | 134 | 15% |