You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, April 2010
|
| DOI | 10.1073/pnas.0910878107 |
| Pubmed ID | |
| Authors |
April J. Ho, Jason L. Stein, Xue Hua, Suh Lee, Derrek P. Hibar, Alex D. Leow, Ivo D. Dinov, Arthur W. Toga, Andrew J. Saykin, Li Shen, Tatiana Foroud, Nathan Pankratz, Matthew J. Huentelman, David W. Craig, Jill D. Gerber, April N. Allen, Jason J. Corneveaux, Dietrich A. Stephan, Charles S. DeCarli, Bryan M. DeChairo, Steven G. Potkin, Clifford R. Jack, Michael W. Weiner, Cyrus A. Raji, Oscar L. Lopez, James T. Becker, Owen T. Carmichael, Paul M. Thompson, Michael Weiner, Leon Thal, Ronald Petersen, Clifford R. Jack, William Jagust, John Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Anthony Gamst, William Z. Potter, Tom Montine, Dale Anders, Matthew Bernstein, Joel Felmlee, Nick Fox, Paul Thompson, Norbert Schuff, Gene Alexander, Dan Bandy, Robert A. Koeppe, Norm Foster, Eric M. Reiman, Kewei Chen, John Trojanowki, Les Shaw, Virginia M.-Y. Lee, Magdalena Korecka, Arthur W. Toga, Karen Crawford, Scott Neu, Danielle Harvey, Anthony Gamst, John Kornak, Zaven Kachaturian, Richard Frank, Peter J. Snyder, Susan Molchan, Jeffrey Kaye, Remi Vorobik, Joseph Quinn, Lon Schneider, Sonia Pawluczyk, Bryan Spann, Adam S. Fleisher, Helen Vanderswag, Judith L. Heidebrink, Joanne L. Lord, Kris Johnson, Rachelle S. Doody, Javier Villanueva-Meyer, Munir Chowdhury, Yaakov Stern, Lawrence S. Honig, Karen L. Bell, John C. Morris, Mark A. Mintun, Stacy Schneider, Daniel Marson, Randall Griffith, Beverly Badger, Hillel Grossman, Cheuk Tang, Jessica Stern, Leyla deToledo-Morrell, Raj C. Shah, Julie Bach, Ranjan Duara, Richard Isaacson, Silvia Strauman, Marilyn S. Albert, Julia Pedroso, Jaimie Toroney, Henry Rusinek, Mony J de Leon, Susan M De Santi, P. Murali Doraiswamy, Jeffrey R. Petrella, Marilyn Aiello, Christopher M. Clark, Cassie Pham, Jessica Nunez, Charles D. Smith, Curtis A. Given, Peter Hardy, Steven T. DeKosky, MaryAnn Oakley, Donna M. Simpson, M. Saleem Ismail, Anton Porsteinsson, Colleen McCallum, Steven C. Cramer, Ruth A. Mulnard, Catherine McAdams-Ortiz, Ramon Diaz-Arrastia, Kristen Martin-Cook, Michael DeVous, Allan I. Levey, James J. Lah, Janet S. Cellar, Jeffrey M. Burns, Heather S. Anderson, Mary M. Laubinger, George Bartzokis, Daniel H.S. Silverman, Po H. Lu, Rita Fletcher, Francine Parfitt, Heather Johnson, Martin Farlow, Scott Herring, Ann M. Hake, Christopher H. van Dyck, Martha G. MacAvoy, Laurel A. Bifano, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra Black, Simon Graham, Curtis Caldwell, Howard Feldman, Michele Assaly, Ging-Yuek R. Hsiung, Andrew Kertesz, John Rogers, Dick Trost, Charles Bernick, Darren Gitelman, Nancy Johnson, Marsel Mesulam, Carl Sadowsky, Teresa Villena, Scott Mesner, Paul S. Aisen, Kathleen B. Johnson, Kelly E. Behan, Reisa A. Sperling, Dorene M. Rentz, Keith A. Johnson, Allyson Rosen, Jared Tinklenberg, Wes Ashford, Marwan Sabbagh, Donald Connor, Sanja Obradov, Ron Killiany, Alex Norbash, Thomas O. Obisesan, Annapurni Jayam-Trouth, Paul Wang, Alexander P. Auchus, Juebin Huang, Robert P. Friedland, Charles DeCarli, Evan Fletcher, Owen Carmichael, Smita Kittur, Seema Mirje, Sterling C. Johnson, Michael Borrie, T-Y Lee, Sanjay Asthana, Cynthia M. Carlsson, Steven G. Potkin, Diane Highum, Adrian Preda, Dana Nguyen, Pierre N. Tariot, Barry A. Hendin, Douglas W. Scharre, Maria Kataki, David Q. Beversdorf, Earl A. Zimmerman, Dzintra Celmins, Alice D. Brown, Sam Gandy, Marjorie E. Marenberg, Barry W. Rovner, Godfrey Pearlson, Karen Blank, Karen Anderson, Andrew J. Saykin, Robert B. Santulli, Nadia Pare, Jeff D. Williamson, Kaycee M. Sink, Huntington Potter, B. Ashok Raj, Amy Giordano, Brian R. Ott, Chuang-Kuo Wu, Ronald Cohen, Kerri L. Wilks |
| Abstract |
A recently identified variant within the fat mass and obesity-associated (FTO) gene is carried by 46% of Western Europeans and is associated with an approximately 1.2 kg higher weight, on average, in adults and an approximately 1 cm greater waist circumference. With >1 billion overweight and 300 million obese persons worldwide, it is crucial to understand the implications of carrying this very common allele for the health of our aging population. FTO is highly expressed in the brain and elevated body mass index (BMI) is associated with brain atrophy, but it is unknown how the obesity-associated risk allele affects human brain structure. We therefore generated 3D maps of regional brain volume differences in 206 healthy elderly subjects scanned with MRI and genotyped as part of the Alzheimer's Disease Neuroimaging Initiative. We found a pattern of systematic brain volume deficits in carriers of the obesity-associated risk allele versus noncarriers. Relative to structure volumes in the mean template, FTO risk allele carriers versus noncarriers had an average brain volume difference of approximately 8% in the frontal lobes and 12% in the occipital lobes-these regions also showed significant volume deficits in subjects with higher BMI. These brain differences were not attributable to differences in cholesterol levels, hypertension, or the volume of white matter hyperintensities; which were not detectably higher in FTO risk allele carriers versus noncarriers. These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 280 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 14 | 5% |
| Switzerland | 2 | <1% |
| Netherlands | 2 | <1% |
| Germany | 2 | <1% |
| United Kingdom | 2 | <1% |
| Brazil | 1 | <1% |
| Australia | 1 | <1% |
| Norway | 1 | <1% |
| Egypt | 1 | <1% |
| Other | 3 | 1% |
| Unknown | 251 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 60 | 21% |
| Student > Ph. D. Student | 53 | 19% |
| Student > Bachelor | 22 | 8% |
| Professor | 21 | 8% |
| Student > Master | 20 | 7% |
| Other | 61 | 22% |
| Unknown | 43 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 51 | 18% |
| Medicine and Dentistry | 49 | 18% |
| Psychology | 35 | 13% |
| Neuroscience | 29 | 10% |
| Biochemistry, Genetics and Molecular Biology | 22 | 8% |
| Other | 36 | 13% |
| Unknown | 58 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 36. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 May 2017.
All research outputs
#1,065,631
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#16,172
of 101,438 outputs
Outputs of similar age
#3,239
of 98,258 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#85
of 748 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 98,258 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 748 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.