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Mendeley readers
Attention Score in Context
| Title |
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24
|
|---|---|
| Published in |
Nature Genetics, March 2009
|
| DOI | 10.1038/ng.333 |
| Pubmed ID | |
| Authors |
Stefanie Birnbaum, Kerstin U Ludwig, Heiko Reutter, Stefan Herms, Michael Steffens, Michele Rubini, Carlotta Baluardo, Melissa Ferrian, Nilma Almeida de Assis, Margrieta A Alblas, Sandra Barth, Jan Freudenberg, Carola Lauster, Gül Schmidt, Martin Scheer, Bert Braumann, Stefaan J Bergé, Rudolf H Reich, Franziska Schiefke, Alexander Hemprich, Simone Pötzsch, Regine P Steegers-Theunissen, Bernd Pötzsch, Susanne Moebus, Bernhard Horsthemke, Franz-Josef Kramer, Thomas F Wienker, Peter A Mossey, Peter Propping, Sven Cichon, Per Hoffmann, Michael Knapp, Markus M Nöthen, Elisabeth Mangold |
| Abstract |
We conducted a genome-wide association study involving 224 cases and 383 controls of Central European origin to identify susceptibility loci for nonsyndromic cleft lip with or without cleft palate (NSCL/P). A 640-kb region at chromosome 8q24.21 was found to contain multiple markers with highly significant evidence for association with the cleft phenotype, including three markers that reached genome-wide significance. The 640-kb cleft-associated region was saturated with 146 SNP markers and then analyzed in our entire NSCL/P sample of 462 unrelated cases and 954 controls. In the entire sample, the most significant SNP (rs987525) had a P value of 3.34 x 10(-24). The odds ratio was 2.57 (95% CI = 2.02-3.26) for the heterozygous genotype and 6.05 (95% CI = 3.88-9.43) for the homozygous genotype. The calculated population attributable risk for this marker is 0.41, suggesting that this study has identified a major susceptibility locus for NSCL/P. |
Mendeley readers
The data shown below were compiled from readership statistics for 185 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| United States | 2 | 1% |
| Brazil | 1 | <1% |
| Japan | 1 | <1% |
| Uruguay | 1 | <1% |
| Unknown | 178 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 33 | 18% |
| Student > Ph. D. Student | 29 | 16% |
| Student > Master | 21 | 11% |
| Student > Bachelor | 17 | 9% |
| Student > Doctoral Student | 16 | 9% |
| Other | 40 | 22% |
| Unknown | 29 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 55 | 30% |
| Agricultural and Biological Sciences | 55 | 30% |
| Biochemistry, Genetics and Molecular Biology | 32 | 17% |
| Mathematics | 2 | 1% |
| Computer Science | 2 | 1% |
| Other | 6 | 3% |
| Unknown | 33 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 January 2017.
All research outputs
#1,608,235
of 22,660,862 outputs
Outputs from Nature Genetics
#2,309
of 7,173 outputs
Outputs of similar age
#4,648
of 92,967 outputs
Outputs of similar age from Nature Genetics
#14
of 61 outputs
Altmetric has tracked 22,660,862 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,173 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 40.9. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 92,967 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.