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The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes

Overview of attention for article published in Science, April 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
6 X users
patent
3 patents
f1000
1 research highlight platform

Citations

dimensions_citation
865 Dimensions

Readers on

mendeley
794 Mendeley
citeulike
25 CiteULike
connotea
15 Connotea
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Title
The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes
Published in
Science, April 2008
DOI 10.1126/science.1150021
Pubmed ID
Authors

Maureen E. Hillenmeyer, Eula Fung, Jan Wildenhain, Sarah E. Pierce, Shawn Hoon, William Lee, Michael Proctor, Robert P. St.Onge, Mike Tyers, Daphne Koller, Russ B. Altman, Ronald W. Davis, Corey Nislow, Guri Giaever

Abstract

Genetics aims to understand the relation between genotype and phenotype. However, because complete deletion of most yeast genes ( approximately 80%) has no obvious phenotypic consequence in rich medium, it is difficult to study their functions. To uncover phenotypes for this nonessential fraction of the genome, we performed 1144 chemical genomic assays on the yeast whole-genome heterozygous and homozygous deletion collections and quantified the growth fitness of each deletion strain in the presence of chemical or environmental stress conditions. We found that 97% of gene deletions exhibited a measurable growth phenotype, suggesting that nearly all genes are essential for optimal growth in at least one condition.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 794 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 35 4%
United Kingdom 8 1%
Germany 5 <1%
France 5 <1%
Switzerland 3 <1%
Canada 3 <1%
Mexico 3 <1%
India 3 <1%
Spain 2 <1%
Other 23 3%
Unknown 704 89%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 216 27%
Researcher 198 25%
Student > Master 66 8%
Professor > Associate Professor 53 7%
Student > Bachelor 51 6%
Other 136 17%
Unknown 74 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 447 56%
Biochemistry, Genetics and Molecular Biology 148 19%
Computer Science 24 3%
Medicine and Dentistry 20 3%
Chemistry 17 2%
Other 57 7%
Unknown 81 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2023.
All research outputs
#1,367,375
of 23,622,736 outputs
Outputs from Science
#21,948
of 78,715 outputs
Outputs of similar age
#3,016
of 82,703 outputs
Outputs of similar age from Science
#75
of 340 outputs
Altmetric has tracked 23,622,736 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 78,715 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 63.4. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 82,703 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 340 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.