Title |
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
|
---|---|
Published in |
Nature Genetics, December 2009
|
DOI | 10.1038/ng.500 |
Pubmed ID | |
Authors |
Dana B Hancock, Mark Eijgelsheim, Jemma B Wilk, Sina A Gharib, Laura R Loehr, Kristin D Marciante, Nora Franceschini, Yannick M T A van Durme, Ting-hsu Chen, R Graham Barr, Matthew B Schabath, David J Couper, Guy G Brusselle, Bruce M Psaty, Cornelia M van Duijn, Jerome I Rotter, André G Uitterlinden, Albert Hofman, Naresh M Punjabi, Fernando Rivadeneira, Alanna C Morrison, Paul L Enright, Kari E North, Susan R Heckbert, Thomas Lumley, Bruno H C Stricker, George T O'Connor, Stephanie J London |
Abstract |
Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV(1)) and its ratio to forced vital capacity (FEV(1)/FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV(1)/FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV(1) (INTS12-GSTCD-NPNT) at or near genome-wide significance (P < 5 x 10(-8)) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 5 | 2% |
Canada | 3 | 1% |
United States | 2 | <1% |
Japan | 2 | <1% |
Germany | 1 | <1% |
Hungary | 1 | <1% |
Norway | 1 | <1% |
Portugal | 1 | <1% |
Mexico | 1 | <1% |
Other | 0 | 0% |
Unknown | 254 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 70 | 26% |
Student > Ph. D. Student | 57 | 21% |
Student > Master | 24 | 9% |
Student > Bachelor | 19 | 7% |
Professor > Associate Professor | 16 | 6% |
Other | 57 | 21% |
Unknown | 28 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 76 | 28% |
Agricultural and Biological Sciences | 68 | 25% |
Biochemistry, Genetics and Molecular Biology | 55 | 20% |
Immunology and Microbiology | 6 | 2% |
Social Sciences | 5 | 2% |
Other | 21 | 8% |
Unknown | 40 | 15% |