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Mendeley readers
Attention Score in Context
| Title |
Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi
|
|---|---|
| Published in |
Nature Genetics, July 2009
|
| DOI | 10.1038/ng.410 |
| Pubmed ID | |
| Authors |
Mario Falchi, Veronique Bataille, Nicholas K Hayward, David L Duffy, Julia A Newton Bishop, Tomi Pastinen, Alessandra Cervino, Zhen Z Zhao, Panos Deloukas, Nicole Soranzo, David E Elder, Jennifer H Barrett, Nicholas G Martin, D Timothy Bishop, Grant W Montgomery, Timothy D Spector |
| Abstract |
A high melanocytic nevi count is the strongest known risk factor for cutaneous melanoma. We conducted a genome-wide association study for nevus count using 297,108 SNPs in 1,524 twins, with validation in an independent cohort of 4,107 individuals. We identified strongly associated variants in MTAP, a gene adjacent to the familial melanoma susceptibility locus CDKN2A on 9p21 (rs4636294, combined P = 3.4 x 10(-15)), as well as in PLA2G6 on 22q13.1 (rs2284063, combined P = 3.4 x 10(-8)). In addition, variants in these two loci showed association with melanoma risk in 3,131 melanoma cases from two independent studies, including rs10757257 at 9p21, combined P = 3.4 x 10(-8), OR = 1.23 (95% CI = 1.15-1.30) and rs132985 at 22q13.1, combined P = 2.6 x 10(-7), OR = 1.23 (95% CI = 1.15-1.30). This provides the first report of common variants associated to nevus number and demonstrates association of these variants with melanoma susceptibility. |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 4% |
| Germany | 1 | <1% |
| Australia | 1 | <1% |
| Italy | 1 | <1% |
| Belgium | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 93 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 24 | 24% |
| Student > Ph. D. Student | 18 | 18% |
| Professor | 9 | 9% |
| Other | 8 | 8% |
| Student > Postgraduate | 8 | 8% |
| Other | 24 | 24% |
| Unknown | 11 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 31% |
| Medicine and Dentistry | 25 | 25% |
| Biochemistry, Genetics and Molecular Biology | 25 | 25% |
| Computer Science | 3 | 3% |
| Philosophy | 1 | <1% |
| Other | 2 | 2% |
| Unknown | 14 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2009.
All research outputs
#1,679,706
of 22,660,862 outputs
Outputs from Nature Genetics
#2,377
of 7,173 outputs
Outputs of similar age
#5,509
of 109,612 outputs
Outputs of similar age from Nature Genetics
#14
of 52 outputs
Altmetric has tracked 22,660,862 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,173 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 40.9. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 109,612 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.