Title |
An illustration of the potential for mapping MRI/MRS parameters with genetic over-expression profiles in human prostate cancer
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Published in |
Magnetic Resonance Materials in Physics, Biology and Medicine, August 2008
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DOI | 10.1007/s10334-008-0133-3 |
Pubmed ID | |
Authors |
Robert E. Lenkinski, B. Nicolas Bloch, Fangbing Liu, John V. Frangioni, Sven Perner, Mark A. Rubin, Elizabeth M. Genega, Neil M. Rofsky, Sandra M. Gaston |
Abstract |
Magnetic resonance imaging (MRI) and MR spectroscopy can probe a variety of physiological (e.g. blood vessel permeability) and metabolic characteristics of prostate cancer. However, little is known about the changes in gene expression that underlie the spectral and imaging features observed in prostate cancer. Tumor induced changes in vascular permeability and angiogenesis are thought to contribute to patterns of dynamic contrast enhanced (DCE) MRI images of prostate cancer even though the genetic basis of tumor vasculogenesis is complex and the specific mechanisms underlying these DCEMRI features have not yet been determined. |
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