Title |
A Deletion in the Chemokine Receptor 5 (CCR5) Gene Is Associated with Tickborne Encephalitis
|
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Published in |
Journal of Infectious Diseases, January 2008
|
DOI | 10.1086/524709 |
Pubmed ID | |
Authors |
Elin Kindberg, Auksė Mickienė, Cecilia Ax, Britt Åkerlind, Sirkka Vene, Lars Lindquist, Åke Lundkvist, Lennart Svensson |
Abstract |
Tickborne encephalitis (TBE) virus infections can be asymptomatic or cause moderate to severe injuries of the central nervous system. Why some individuals develop severe disease is unknown, but a role for host genetic factors has been suggested. To investigate whether chemokine receptor CCR5 is associated with TBE, CCR5Delta32 genotyping was performed among Lithuanian patients with TBE (n=129) or with aseptic meningoencephalitis (n=76) as well as among control subjects (n=134). We found individuals homozygous for CCR5Delta32 (P= .026) only among patients with TBE and a higher allele prevalence among patients with TBE compared with the other groups studied. CCR5Delta32 allele prevalence also increased with the clinical severity of disease. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 2% |
Unknown | 58 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 20% |
Researcher | 10 | 17% |
Student > Bachelor | 7 | 12% |
Student > Master | 7 | 12% |
Other | 5 | 8% |
Other | 10 | 17% |
Unknown | 8 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 20% |
Biochemistry, Genetics and Molecular Biology | 10 | 17% |
Immunology and Microbiology | 9 | 15% |
Medicine and Dentistry | 8 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 8 | 14% |
Unknown | 10 | 17% |