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Efficient colonic mucosal wound repair requires Trem2 signaling

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, January 2009
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  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Average Attention Score compared to outputs of the same age and source

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1 X user
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20 patents
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Citations

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231 Dimensions

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233 Mendeley
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1 CiteULike
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Title
Efficient colonic mucosal wound repair requires Trem2 signaling
Published in
Proceedings of the National Academy of Sciences of the United States of America, January 2009
DOI 10.1073/pnas.0803343106
Pubmed ID
Authors

Hiroshi Seno, Hiroyuki Miyoshi, Sarah L. Brown, Michael J. Geske, Marco Colonna, Thaddeus S. Stappenbeck

Abstract

The colonic epithelial lining undergoes constant replacement, driven by epithelial stem cells in crypts of Lieberkühn. Stem cells lost because of damage or disease can be replaced by adjacent crypts that undergo fission. The close proximity of an extraordinary number of luminal microbes creates a challenge for this repair process; infection must be prevented while immune system activation and epithelial stem cell genetic damage must be minimized. To understand the factors that modulate crypt/stem cell replacement in the mouse colon, we developed an in vivo acute injury system analogous to punch biopsy of the skin. In contrast to epidermal stem cells, colonic epithelial progenitors did not migrate over the wound bed. Instead, their proliferative expansion was confined to crypts adjacent to wound beds and was delayed to the latter phase of healing. This increased epithelial proliferation was coincident with the infiltration of Trem2 expressing macrophages and increased expression of IL-4 and IL-13 in the wound bed. Interestingly, Trem2(-/-) mice displayed slow and incomplete wound healing of colonic mucosal injuries. We found the latter phase of healing in Trem2(-/-) mice showed a diminished burst of epithelial proliferation, increased expression of IFN-gamma and TNF-alpha, diminished expression of IL-4 and IL-13, and increased markers of classical macrophage activation. Ablation of these cytokines in injured WT and Trem2(-/-) mice demonstrated that their expression ultimately determined the rate and nature of wound healing. These studies show that Trem2 signaling is an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 233 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 1%
Mexico 1 <1%
United Kingdom 1 <1%
Unknown 228 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 65 28%
Researcher 46 20%
Student > Bachelor 23 10%
Student > Master 17 7%
Student > Doctoral Student 10 4%
Other 29 12%
Unknown 43 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 53 23%
Medicine and Dentistry 45 19%
Biochemistry, Genetics and Molecular Biology 31 13%
Immunology and Microbiology 24 10%
Pharmacology, Toxicology and Pharmaceutical Science 8 3%
Other 21 9%
Unknown 51 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2023.
All research outputs
#6,497,958
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#57,658
of 101,438 outputs
Outputs of similar age
#41,881
of 180,231 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#374
of 650 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 180,231 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 650 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.