| Title |
An Evolutionary Footprint of Age-Related Natural Selection in Mitochondrial DNA
|
|---|---|
| Published in |
Journal of Molecular Evolution, September 2008
|
| DOI | 10.1007/s00239-008-9163-8 |
| Pubmed ID | |
| Authors |
Xiang Jia Min, Donal A. Hickey |
| Abstract |
By comparing mtDNA sequences between different orders of mammals, we show that both longevity and generation time are significantly correlated with the nucleotide content of the mtDNA. Specifically, there is a positive correlation between generation time and mt GC content. This correlation is repeated, at a finer evolutionary scale, within the primates. Moreover, a comparison of human and chimpanzee mtDNAs shows that the effect has been very pronounced during the short evolutionary period since the divergence of these two species, with human mtDNA showing a GC-biased pattern of substitution at the variable sites. In addition to these DNA sequence patterns, comparisons between the human and the chimp mt protein sequences also revealed a surprisingly high substitution rate for threonine residues, resulting in a reduction of threonine in the human mt proteome. These patterns of both DNA and protein evolution can be explained by a balance between AT-biased mutational pressure and age-related purifying selection. |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Germany | 1 | 3% |
| France | 1 | 3% |
| Brazil | 1 | 3% |
| Unknown | 36 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 48% |
| Student > Ph. D. Student | 8 | 20% |
| Professor | 3 | 8% |
| Professor > Associate Professor | 3 | 8% |
| Student > Doctoral Student | 2 | 5% |
| Other | 4 | 10% |
| Unknown | 1 | 3% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 26 | 65% |
| Biochemistry, Genetics and Molecular Biology | 5 | 13% |
| Unspecified | 1 | 3% |
| Computer Science | 1 | 3% |
| Decision Sciences | 1 | 3% |
| Other | 4 | 10% |
| Unknown | 2 | 5% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2008.
All research outputs
#15,240,835
of 22,660,862 outputs
Outputs from Journal of Molecular Evolution
#1,148
of 1,436 outputs
Outputs of similar age
#74,362
of 87,720 outputs
Outputs of similar age from Journal of Molecular Evolution
#10
of 11 outputs
Altmetric has tracked 22,660,862 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,436 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 87,720 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.