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Regulation of alternative polyadenylation by genomic imprinting

Overview of attention for article published in Genes & Development, May 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

Mentioned by

twitter
1 X user
patent
1 patent
wikipedia
4 Wikipedia pages
f1000
1 research highlight platform

Citations

dimensions_citation
130 Dimensions

Readers on

mendeley
136 Mendeley
citeulike
7 CiteULike
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1 Connotea
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Title
Regulation of alternative polyadenylation by genomic imprinting
Published in
Genes & Development, May 2008
DOI 10.1101/gad.473408
Pubmed ID
Authors

Andrew J. Wood, Reiner Schulz, Kathryn Woodfine, Katarzyna Koltowska, Colin V. Beechey, Jo Peters, Deborah Bourc’his, Rebecca J. Oakey

Abstract

Maternally and paternally derived alleles can utilize different promoters, but allele-specific differences in cotranscriptional processes have not been reported. We show that alternative polyadenylation sites at a novel murine imprinted gene (H13) are utilized in an allele-specific manner. A differentially methylated CpG island separates polyA sites utilized on maternal and paternal alleles, and contains an internal promoter. Two genetic systems show that alleles lacking methylation generate truncated H13 transcripts that undergo internal polyadenylation. On methylated alleles, the internal promoter is inactive and elongation proceeds to downstream polyadenylation sites. This demonstrates that epigenetic modifications can influence utilization of alternative polyadenylation sites.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 4%
United Kingdom 3 2%
Netherlands 1 <1%
Italy 1 <1%
Belgium 1 <1%
Portugal 1 <1%
Japan 1 <1%
China 1 <1%
Unknown 122 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 32 24%
Researcher 32 24%
Student > Master 15 11%
Student > Bachelor 11 8%
Professor > Associate Professor 10 7%
Other 9 7%
Unknown 27 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 74 54%
Biochemistry, Genetics and Molecular Biology 26 19%
Medicine and Dentistry 3 2%
Veterinary Science and Veterinary Medicine 1 <1%
Earth and Planetary Sciences 1 <1%
Other 3 2%
Unknown 28 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2023.
All research outputs
#4,208,421
of 23,549,388 outputs
Outputs from Genes & Development
#1,556
of 5,879 outputs
Outputs of similar age
#13,536
of 80,433 outputs
Outputs of similar age from Genes & Development
#17
of 49 outputs
Altmetric has tracked 23,549,388 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,879 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 80,433 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.