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Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure

Overview of attention for article published in Kidney International, July 2010
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  • Good Attention Score compared to outputs of the same age (65th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

Mentioned by

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2 patents
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1 research highlight platform

Citations

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33 Dimensions

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30 Mendeley
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Title
Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure
Published in
Kidney International, July 2010
DOI 10.1038/ki.2010.217
Pubmed ID
Authors

Surjit K. Srai, Bomee Chung, Joanne Marks, Katayoun Pourvali, Nita Solanky, Chiara Rapisarda, Timothy B. Chaston, Rumeza Hanif, Robert J. Unwin, Edward S. Debnam, Paul A. Sharp

Abstract

Erythropoietin is produced by the kidney and stimulates erythropoiesis; however, in chronic renal disease its levels are reduced and patients develop anemia that is treatable with iron and recombinant hormone. The mechanism by which erythropoietin improves iron homeostasis is still unclear, but it may involve suppression of the iron regulatory peptide hepcidin and/or a direct effect on intestinal iron absorption. To investigate these possibilities, we used the well-established 5/6th nephrectomy rat model of chronic renal failure with or without human recombinant erythropoietin treatment. Monolayers of human intestinal Caco-2 cells were also treated with erythropoietin to measure any direct effects of this hormone on intestinal iron transport. Nephrectomy increased hepatic hepcidin expression and decreased intestinal iron absorption; these effects were restored to levels found in sham-operated rats on erythropoietin treatment of the rats with renal failure. In Caco-2 cells, the addition of erythropoietin significantly increased the expression of apical divalent metal transporter 1 (DMT1) and basolateral ferroportin and, consequently, iron transport across the monolayer. Taken together, our results show that erythropoietin not only exerts a powerful inhibitory action on the expression of hepcidin, thus permitting the release of iron from reticuloendothelial macrophages and intestinal enterocytes, but also acts directly on enterocytes to increase iron absorption.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 3%
Australia 1 3%
Unknown 28 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 30%
Other 4 13%
Student > Bachelor 3 10%
Student > Ph. D. Student 3 10%
Professor 3 10%
Other 5 17%
Unknown 3 10%
Readers by discipline Count As %
Medicine and Dentistry 11 37%
Agricultural and Biological Sciences 5 17%
Biochemistry, Genetics and Molecular Biology 4 13%
Neuroscience 2 7%
Immunology and Microbiology 2 7%
Other 2 7%
Unknown 4 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2022.
All research outputs
#7,355,930
of 25,374,647 outputs
Outputs from Kidney International
#3,151
of 7,405 outputs
Outputs of similar age
#33,820
of 104,871 outputs
Outputs of similar age from Kidney International
#20
of 47 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 7,405 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.9. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 104,871 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.