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Mendeley readers
Attention Score in Context
| Title |
SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation
|
|---|---|
| Published in |
Nature Genetics, April 2008
|
| DOI | 10.1038/ng.142 |
| Pubmed ID | |
| Authors |
Marnie E Blewitt, Anne-Valerie Gendrel, Zhenyi Pang, Duncan B Sparrow, Nadia Whitelaw, Jeffrey M Craig, Anwyn Apedaile, Douglas J Hilton, Sally L Dunwoodie, Neil Brockdorff, Graham F Kay, Emma Whitelaw |
| Abstract |
X-chromosome inactivation is the mammalian dosage compensation mechanism by which transcription of X-linked genes is equalized between females and males. In an N-ethyl-N-nitrosourea (ENU) mutagenesis screen on mice for modifiers of epigenetic reprogramming, we identified the MommeD1 (modifier of murine metastable epialleles) mutation as a semidominant suppressor of variegation. MommeD1 shows homozygous female-specific mid-gestation lethality and hypomethylation of the X-linked gene Hprt1, suggestive of a defect in X inactivation. Here we report that the causative point mutation lies in a previously uncharacterized gene, Smchd1 (structural maintenance of chromosomes hinge domain containing 1). We find that SmcHD1 is not required for correct Xist expression, but localizes to the inactive X and has a role in the maintenance of X inactivation and the hypermethylation of CpG islands associated with the inactive X. This finding links a group of proteins normally associated with structural aspects of chromosome biology with epigenetic gene silencing. |
Mendeley readers
The data shown below were compiled from readership statistics for 234 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 3% |
| United Kingdom | 4 | 2% |
| Japan | 2 | <1% |
| France | 1 | <1% |
| Singapore | 1 | <1% |
| Unknown | 220 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 56 | 24% |
| Researcher | 44 | 19% |
| Student > Bachelor | 27 | 12% |
| Student > Master | 23 | 10% |
| Professor > Associate Professor | 18 | 8% |
| Other | 33 | 14% |
| Unknown | 33 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 100 | 43% |
| Biochemistry, Genetics and Molecular Biology | 71 | 30% |
| Medicine and Dentistry | 14 | 6% |
| Chemistry | 4 | 2% |
| Neuroscience | 4 | 2% |
| Other | 6 | 3% |
| Unknown | 35 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2020.
All research outputs
#3,919,343
of 26,017,215 outputs
Outputs from Nature Genetics
#3,946
of 7,655 outputs
Outputs of similar age
#11,895
of 97,145 outputs
Outputs of similar age from Nature Genetics
#42
of 66 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,655 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.8. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 97,145 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.