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Mendeley readers
Attention Score in Context
| Title |
Modulation of Shigella virulence in response to available oxygen in vivo
|
|---|---|
| Published in |
Nature, May 2010
|
| DOI | 10.1038/nature08970 |
| Pubmed ID | |
| Authors |
Benoit Marteyn, Nicholas P. West, Douglas F. Browning, Jeffery A. Cole, Jonathan G. Shaw, Fredrik Palm, Joelle Mounier, Marie-Christine Prévost, Philippe Sansonetti, Christoph M. Tang |
| Abstract |
Bacteria coordinate expression of virulence determinants in response to localized microenvironments in their hosts. Here we show that Shigella flexneri, which causes dysentery, encounters varying oxygen concentrations in the gastrointestinal tract, which govern activity of its type three secretion system (T3SS). The T3SS is essential for cell invasion and virulence. In anaerobic environments (for example, the gastrointestinal tract lumen), Shigella is primed for invasion and expresses extended T3SS needles while reducing Ipa (invasion plasmid antigen) effector secretion. This is mediated by FNR (fumarate and nitrate reduction), a regulator of anaerobic metabolism that represses transcription of spa32 and spa33, virulence genes that regulate secretion through the T3SS. We demonstrate there is a zone of relative oxygenation adjacent to the gastrointestinal tract mucosa, caused by diffusion from the capillary network at the tips of villi. This would reverse the anaerobic block of Ipa secretion, allowing T3SS activation at its precise site of action, enhancing invasion and virulence. |
Mendeley readers
The data shown below were compiled from readership statistics for 301 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 2% |
| United Kingdom | 3 | <1% |
| Chile | 1 | <1% |
| Israel | 1 | <1% |
| Peru | 1 | <1% |
| Switzerland | 1 | <1% |
| Spain | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 286 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 78 | 26% |
| Researcher | 76 | 25% |
| Student > Master | 32 | 11% |
| Student > Bachelor | 26 | 9% |
| Student > Doctoral Student | 14 | 5% |
| Other | 47 | 16% |
| Unknown | 28 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 132 | 44% |
| Biochemistry, Genetics and Molecular Biology | 61 | 20% |
| Immunology and Microbiology | 42 | 14% |
| Medicine and Dentistry | 12 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 2% |
| Other | 18 | 6% |
| Unknown | 30 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2014.
All research outputs
#4,144,328
of 22,660,862 outputs
Outputs from Nature
#53,027
of 90,600 outputs
Outputs of similar age
#17,614
of 95,139 outputs
Outputs of similar age from Nature
#371
of 585 outputs
Altmetric has tracked 22,660,862 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 90,600 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 99.2. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,139 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 585 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.