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Mendeley readers
Attention Score in Context
| Title |
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
|
|---|---|
| Published in |
Nature Genetics, April 2010
|
| DOI | 10.1038/ng.567 |
| Pubmed ID | |
| Authors |
Rachel M Freathy, Dennis O Mook-Kanamori, Ulla Sovio, Inga Prokopenko, Nicholas J Timpson, Diane J Berry, Nicole M Warrington, Elisabeth Widen, Jouke Jan Hottenga, Marika Kaakinen, Leslie A Lange, Jonathan P Bradfield, Marjan Kerkhof, Julie A Marsh, Reedik Mägi, Chih-Mei Chen, Helen N Lyon, Mirna Kirin, Linda S Adair, Yurii S Aulchenko, Amanda J Bennett, Judith B Borja, Nabila Bouatia-Naji, Pimphen Charoen, Lachlan J M Coin, Diana L Cousminer, Eco J C de Geus, Panos Deloukas, Paul Elliott, David M Evans, Philippe Froguel, Beate Glaser, Christopher J Groves, Anna-Liisa Hartikainen, Neelam Hassanali, Joel N Hirschhorn, Albert Hofman, Jeff M P Holly, Elina Hyppönen, Stavroula Kanoni, Bridget A Knight, Jaana Laitinen, Cecilia M Lindgren, Wendy L McArdle, Paul F O'Reilly, Craig E Pennell, Dirkje S Postma, Anneli Pouta, Adaikalavan Ramasamy, Nigel W Rayner, Susan M Ring, Fernando Rivadeneira, Beverley M Shields, David P Strachan, Ida Surakka, Anja Taanila, Carla Tiesler, Andre G Uitterlinden, Cornelia M van Duijn, Alet H Wijga, Gonneke Willemsen, Haitao Zhang, Jianhua Zhao, James F Wilson, Eric A P Steegers, Andrew T Hattersley, Johan G Eriksson, Leena Peltonen, Karen L Mohlke, Struan F A Grant, Hakon Hakonarson, Gerard H Koppelman, George V Dedoussis, Joachim Heinrich, Matthew W Gillman, Lyle J Palmer, Timothy M Frayling, Dorret I Boomsma, George Davey Smith, Chris Power, Vincent W V Jaddoe, Marjo-Riitta Jarvelin |
| Abstract |
To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 x 10(-35)) and rs9883204 in ADCY5 (P = 7 x 10(-15)) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113 g (95% CI 89-137 g) lighter at birth than the 24% with zero or one alleles (P(trend) = 7 x 10(-30)). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy. |
Mendeley readers
The data shown below were compiled from readership statistics for 200 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 3% |
| United States | 3 | 2% |
| Brazil | 1 | <1% |
| Germany | 1 | <1% |
| Mexico | 1 | <1% |
| Norway | 1 | <1% |
| Unknown | 188 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 51 | 26% |
| Student > Ph. D. Student | 35 | 18% |
| Professor | 21 | 11% |
| Student > Master | 18 | 9% |
| Professor > Associate Professor | 9 | 5% |
| Other | 35 | 18% |
| Unknown | 31 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 53 | 27% |
| Medicine and Dentistry | 42 | 21% |
| Biochemistry, Genetics and Molecular Biology | 25 | 13% |
| Social Sciences | 6 | 3% |
| Computer Science | 6 | 3% |
| Other | 28 | 14% |
| Unknown | 40 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 December 2023.
All research outputs
#2,248,343
of 26,017,215 outputs
Outputs from Nature Genetics
#2,875
of 7,639 outputs
Outputs of similar age
#8,050
of 107,305 outputs
Outputs of similar age from Nature Genetics
#15
of 47 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,639 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.7. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 107,305 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.