Title |
New susceptibility locus for coronary artery disease on chromosome 3q22.3
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Published in |
Nature Genetics, February 2009
|
DOI | 10.1038/ng.307 |
Pubmed ID | |
Authors |
Jeanette Erdmann, Anika Großhennig, Peter S Braund, Inke R König, Christian Hengstenberg, Alistair S Hall, Patrick Linsel-Nitschke, Sekar Kathiresan, Ben Wright, David-Alexandre Trégouët, Francois Cambien, Petra Bruse, Zouhair Aherrahrou, Arnika K Wagner, Klaus Stark, Stephen M Schwartz, Veikko Salomaa, Roberto Elosua, Olle Melander, Benjamin F Voight, Christopher J O'Donnell, Leena Peltonen, David S Siscovick, David Altshuler, Piera Angelica Merlini, Flora Peyvandi, Luisa Bernardinelli, Diego Ardissino, Arne Schillert, Stefan Blankenberg, Tanja Zeller, Philipp Wild, Daniel F Schwarz, Laurence Tiret, Claire Perret, Stefan Schreiber, Nour Eddine El Mokhtari, Arne Schäfer, Winfried März, Wilfried Renner, Peter Bugert, Harald Klüter, Jürgen Schrezenmeir, Diana Rubin, Stephen G Ball, Anthony J Balmforth, H-Erich Wichmann, Thomas Meitinger, Marcus Fischer, Christa Meisinger, Jens Baumert, Annette Peters, Willem H Ouwehand, Panos Deloukas, John R Thompson, Andreas Ziegler, Nilesh J Samani, Heribert Schunkert |
Abstract |
We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 4 | 1% |
United States | 4 | 1% |
United Kingdom | 3 | <1% |
Brazil | 2 | <1% |
Canada | 2 | <1% |
Uruguay | 1 | <1% |
Sweden | 1 | <1% |
Netherlands | 1 | <1% |
France | 1 | <1% |
Other | 2 | <1% |
Unknown | 362 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 63 | 16% |
Student > Ph. D. Student | 46 | 12% |
Professor > Associate Professor | 21 | 5% |
Professor | 20 | 5% |
Student > Master | 17 | 4% |
Other | 39 | 10% |
Unknown | 177 | 46% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 83 | 22% |
Medicine and Dentistry | 52 | 14% |
Biochemistry, Genetics and Molecular Biology | 34 | 9% |
Mathematics | 6 | 2% |
Chemistry | 3 | <1% |
Other | 13 | 3% |
Unknown | 192 | 50% |