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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Direct measurement of somatic voltage clamp errors in central neurons
|
|---|---|
| Published in |
Nature Neuroscience, June 2008
|
| DOI | 10.1038/nn.2137 |
| Pubmed ID | |
| Authors |
Stephen R Williams, Simon J Mitchell |
| Abstract |
The somatic voltage clamp technique has revolutionized understanding of synaptic physiology and the excitability of neurons. Although computer simulations have indicated that the somatic voltage clamp poorly controls voltage in the dendritic tree of neurons, where the majority of synaptic contacts are made, there has not been an experimental description of the performance of the somatic voltage clamp. Here, we directly quantify errors in the measurement of dendritic synaptic input by the somatic voltage clamp using simultaneous whole-cell recordings from the soma and apical dendrite of rat neocortical pyramidal neurons. The somatic voltage clamp did not control voltage at sites other than the soma and distorted measurement of the amplitude, kinetics, slope conductance and reversal potential of synaptic inputs in a dendritic distance-dependent manner. These errors question the use of the somatic voltage clamp as a quantitative tool in dendritic neurons. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Scientists | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 540 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 22 | 4% |
| Germany | 7 | 1% |
| United Kingdom | 6 | 1% |
| France | 4 | <1% |
| Japan | 4 | <1% |
| Portugal | 4 | <1% |
| Chile | 2 | <1% |
| Netherlands | 2 | <1% |
| Finland | 1 | <1% |
| Other | 6 | 1% |
| Unknown | 482 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 151 | 28% |
| Researcher | 145 | 27% |
| Student > Master | 40 | 7% |
| Professor > Associate Professor | 37 | 7% |
| Professor | 36 | 7% |
| Other | 79 | 15% |
| Unknown | 52 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 250 | 46% |
| Neuroscience | 155 | 29% |
| Medicine and Dentistry | 20 | 4% |
| Engineering | 12 | 2% |
| Biochemistry, Genetics and Molecular Biology | 11 | 2% |
| Other | 33 | 6% |
| Unknown | 59 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2023.
All research outputs
#2,463,023
of 24,079,362 outputs
Outputs from Nature Neuroscience
#2,594
of 5,411 outputs
Outputs of similar age
#6,691
of 84,939 outputs
Outputs of similar age from Nature Neuroscience
#8
of 45 outputs
Altmetric has tracked 24,079,362 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,411 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.9. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 84,939 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.