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BAFF and MyD88 signals promote a lupuslike disease independent of T cells

Overview of attention for article published in The Journal of Experimental Medicine, July 2007
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

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1 blog
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2 patents
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1 research highlight platform

Citations

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328 Dimensions

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156 Mendeley
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2 CiteULike
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Title
BAFF and MyD88 signals promote a lupuslike disease independent of T cells
Published in
The Journal of Experimental Medicine, July 2007
DOI 10.1084/jem.20062567
Pubmed ID
Authors

Joanna R. Groom, Carrie A. Fletcher, Stacey N. Walters, Shane T. Grey, Sally V. Watt, Mathew J. Sweet, Mark J. Smyth, Charles R. Mackay, Fabienne Mackay

Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the production of autoantibodies. However, the underlying cause of disease appears to relate to defects in T cell tolerance or T cell help to B cells. Transgenic (Tg) mice overexpressing the cytokine B cell-activating factor of the tumor necrosis factor family (BAFF) develop an autoimmune disorder similar to SLE and show impaired B cell tolerance and altered T cell differentiation. We generated BAFF Tg mice that were completely deficient in T cells, and, surprisingly, these mice developed an SLE-like disease indistinguishable from that of BAFF Tg mice. Autoimmunity in BAFF Tg mice did, however, require B cell-intrinsic signals through the Toll-like receptor (TLR)-associated signaling adaptor MyD88, which controlled the production of proinflammatory autoantibody isotypes. TLR7/9 activation strongly up-regulated expression of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI), which is a receptor for BAFF involved in B cell responses to T cell-independent antigens. Moreover, BAFF enhanced TLR7/9 expression on B cells and TLR-mediated production of autoantibodies. Therefore, autoimmunity in BAFF Tg mice results from altered B cell tolerance, but requires TLR signaling and is independent of T cell help. It is possible that SLE patients with elevated levels of BAFF show a similar basis for disease.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 156 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 2 1%
United States 2 1%
Germany 1 <1%
Unknown 151 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 35 22%
Researcher 33 21%
Student > Bachelor 16 10%
Student > Doctoral Student 10 6%
Professor > Associate Professor 10 6%
Other 30 19%
Unknown 22 14%
Readers by discipline Count As %
Medicine and Dentistry 46 29%
Agricultural and Biological Sciences 43 28%
Immunology and Microbiology 25 16%
Biochemistry, Genetics and Molecular Biology 12 8%
Chemistry 3 2%
Other 5 3%
Unknown 22 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2023.
All research outputs
#3,779,497
of 25,374,917 outputs
Outputs from The Journal of Experimental Medicine
#2,653
of 11,599 outputs
Outputs of similar age
#9,099
of 76,106 outputs
Outputs of similar age from The Journal of Experimental Medicine
#11
of 50 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,599 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.4. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,106 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.