| Title |
3D microfilter device for viable circulating tumor cell (CTC) enrichment from blood
|
|---|---|
| Published in |
Biomedical Microdevices, October 2010
|
| DOI | 10.1007/s10544-010-9485-3 |
| Pubmed ID | |
| Authors |
Siyang Zheng, Henry K. Lin, Bo Lu, Anthony Williams, Ram Datar, Richard J. Cote, Yu-Chong Tai |
| Abstract |
Detection of circulating tumor cells has emerged as a promising minimally invasive diagnostic and prognostic tool for patients with metastatic cancers. We report a novel three dimensional microfilter device that can enrich viable circulating tumor cells from blood. This device consists of two layers of parylene membrane with pores and gap precisely defined with photolithography. The positions of the pores are shifted between the top and bottom membranes. The bottom membrane supports captured cells and minimize the stress concentration on cell membrane and sustain cell viability during filtration. Viable cell capture on device was investigated with scanning electron microscopy, confocal microscopy, and immunofluorescent staining using model systems of cultured tumor cells spiked in blood or saline. The paper presents and validates this new 3D microfiltration concept for circulation tumor cell enrichment application. The device provides a highly valuable tool for assessing and characterizing viable enriched circulating tumor cells in both research and clinical settings. |
Mendeley readers
The data shown below were compiled from readership statistics for 317 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 3 | <1% |
| Switzerland | 2 | <1% |
| United States | 2 | <1% |
| Netherlands | 1 | <1% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Saudi Arabia | 1 | <1% |
| Sweden | 1 | <1% |
| Other | 4 | 1% |
| Unknown | 300 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 77 | 24% |
| Researcher | 50 | 16% |
| Student > Master | 46 | 15% |
| Student > Bachelor | 36 | 11% |
| Professor | 16 | 5% |
| Other | 38 | 12% |
| Unknown | 54 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 113 | 36% |
| Agricultural and Biological Sciences | 37 | 12% |
| Medicine and Dentistry | 29 | 9% |
| Biochemistry, Genetics and Molecular Biology | 26 | 8% |
| Chemistry | 13 | 4% |
| Other | 30 | 9% |
| Unknown | 69 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2024.
All research outputs
#1,486,361
of 23,485,204 outputs
Outputs from Biomedical Microdevices
#9
of 762 outputs
Outputs of similar age
#5,227
of 100,830 outputs
Outputs of similar age from Biomedical Microdevices
#1
of 14 outputs
Altmetric has tracked 23,485,204 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 762 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 100,830 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.