| Title |
Parathyroid Hormone and Bone Healing
|
|---|---|
| Published in |
Calcified Tissue International, April 2010
|
| DOI | 10.1007/s00223-010-9360-5 |
| Pubmed ID | |
| Authors |
M. Ellegaard, N. R. Jørgensen, P. Schwarz |
| Abstract |
Fracture healing is a complex process, and a significant number of fractures are complicated by impaired healing and non-union. Impaired healing is prevalent in certain risk groups, such as the elderly, osteoporotics, people with malnutrition, and women after menopause. Currently, no pharmacological treatments are available. There is therefore an unmet need for medications that can stimulate bone healing. Parathyroid hormone (PTH) is the first bone anabolic drug approved for the treatment of osteoporosis, and intriguingly a number of animal studies suggest that PTH could be beneficial in the treatment of fractures and could thus be a potentially new treatment option for induction of fracture healing in humans. Furthermore, fractures in animals with experimental conditions of impaired healing such as aging, estrogen withdrawal, and malnutrition can heal in an expedited manner after PTH treatment. Interestingly, fractures occurring at both cancellous and cortical sites can be treated successfully, indicating that both osteoporotic and nonosteoporotic fractures can be the target of PTH-induced healing. Finally, the data suggest that PTH partly prevents the delay in fracture healing caused by aging. Recently, the first randomized, controlled clinical trial investigating the effect of PTH on fracture healing was published, indicating a possible clinical benefit of PTH treatment in inducing fracture healing. The aim of this article is therefore to review the evidence for the potential of PTH in bone healing, including the underlying mechanisms for this, and to provide recommendations for the clinical testing and use of PTH in the treatment of impaired fracture healing in humans. |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 81 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 18% |
| Researcher | 12 | 15% |
| Student > Master | 11 | 13% |
| Professor | 5 | 6% |
| Student > Doctoral Student | 5 | 6% |
| Other | 19 | 23% |
| Unknown | 15 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 41% |
| Agricultural and Biological Sciences | 16 | 20% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Engineering | 3 | 4% |
| Nursing and Health Professions | 2 | 2% |
| Other | 5 | 6% |
| Unknown | 17 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 May 2010.
All research outputs
#15,240,835
of 22,660,862 outputs
Outputs from Calcified Tissue International
#1,335
of 1,755 outputs
Outputs of similar age
#77,574
of 95,336 outputs
Outputs of similar age from Calcified Tissue International
#7
of 9 outputs
Altmetric has tracked 22,660,862 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,755 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
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We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.