| Title |
Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo
|
|---|---|
| Published in |
Experimental Brain Research, November 2011
|
| DOI | 10.1007/s00221-011-2911-9 |
| Pubmed ID | |
| Authors |
Peter Jedlicka, Mirka Owen, Matej Vnencak, Jakob-A. Tschäpe, Meike Hick, Ulrike C. Müller, Thomas Deller |
| Abstract |
The amyloid precursor protein (APP) plays a crucial role in the pathogenesis of Alzheimer's disease. Here, we studied whether the lack of APP affects the synaptic properties in the dentate gyrus by measuring granule cell field potentials evoked by perforant path stimulation in anesthetized 9-11-month-old APP-deficient mice in vivo. We found decreased paired-pulse facilitation, indicating altered presynaptic short-term plasticity in the APP-deficient dentate gyrus. In contrast, excitatory synaptic strength and granule cell firing were unchanged in APP knockout mice. Likewise, long-term potentiation (LTP) induced by a theta-burst stimulation protocol was not impaired in the absence of APP. These findings suggest that the deletion of APP may affect presynaptic plasticity of synaptic transmission at the perforant path-granule cell synapse but leaves synaptic efficacy intact and LTP preserved, possibly due to functional redundancy within the APP gene family. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 7% |
| Mexico | 1 | 2% |
| Unknown | 41 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 27% |
| Researcher | 11 | 24% |
| Student > Doctoral Student | 7 | 16% |
| Student > Bachelor | 3 | 7% |
| Other | 2 | 4% |
| Other | 4 | 9% |
| Unknown | 6 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 42% |
| Neuroscience | 9 | 20% |
| Medicine and Dentistry | 6 | 13% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Immunology and Microbiology | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 8 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 December 2011.
All research outputs
#18,303,139
of 22,660,862 outputs
Outputs from Experimental Brain Research
#2,473
of 3,215 outputs
Outputs of similar age
#116,702
of 142,156 outputs
Outputs of similar age from Experimental Brain Research
#26
of 35 outputs
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