Title |
Helicobacter pylori cagA gene variants in Malaysians of different ethnicity
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Published in |
European Journal of Clinical Microbiology & Infectious Diseases, February 2009
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DOI | 10.1007/s10096-009-0712-x |
Pubmed ID | |
Authors |
Ramelah Mohamed, Alfizah Hanafiah, Isa M. Rose, Mohd Rizal A. Manaf, Shiekh Anwar Abdullah, Ismail Sagap, A. van Belkum, Jasmi A. Yaacob |
Abstract |
We have defined DNA repeat variability in the 3'-terminus of the cagA gene of Helicobacter pylori strains from Malaysian patients of different ethnicities. We identified different alleles based on the EPIYA repeats. cagA types A-B-D and A-B-B-D are more similar to the sequence of Japanese strains, whereas cagA types A-B-C, A-B-C-C, A-B and A-C displayed similarity to strain 26695 sequences. A significant association was found between cagA genotypes and patients' ethnicity, with cagA type A-B-D being predominantly isolated from Chinese patients and cagA type A-B-C from Malays and Indians. Our data further corroborate the possibility that variant biological activity of CagA may affect the host specificity and/or pathogenicity of H. pylori. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 22% |
Other | 3 | 17% |
Researcher | 3 | 17% |
Lecturer | 2 | 11% |
Professor | 1 | 6% |
Other | 3 | 17% |
Unknown | 2 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 22% |
Medicine and Dentistry | 4 | 22% |
Agricultural and Biological Sciences | 3 | 17% |
Immunology and Microbiology | 2 | 11% |
Computer Science | 1 | 6% |
Other | 2 | 11% |
Unknown | 2 | 11% |