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Mendeley readers
Attention Score in Context
| Title |
CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, April 2011
|
| DOI | 10.1073/pnas.1103782108 |
| Pubmed ID | |
| Authors |
Alice McNally, Geoffrey R. Hill, Tim Sparwasser, Ranjeny Thomas, Raymond J. Steptoe |
| Abstract |
CD4(+)CD25(+) regulatory T cells (Treg) play a crucial role in the regulation of immune responses. Although many mechanisms of Treg suppression in vitro have been described, the mechanisms by which Treg modulate CD8(+) T cell differentiation and effector function in vivo are more poorly defined. It has been proposed, in many instances, that modulation of cytokine homeostasis could be an important mechanism by which Treg regulate adaptive immunity; however, direct experimental evidence is sparse. Here we demonstrate that CD4(+)CD25(+) Treg, by critically regulating IL-2 homeostasis, modulate CD8(+) T-cell effector differentiation. Expansion and effector differentiation of CD8(+) T cells is promoted by autocrine IL-2 but, by competing for IL-2, Treg limit CD8(+) effector differentiation. Furthermore, a regulatory loop exists between Treg and CD8(+) effector T cells, where IL-2 produced during CD8(+) T-cell effector differentiation promotes Treg expansion. |
Mendeley readers
The data shown below were compiled from readership statistics for 166 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Portugal | 1 | <1% |
| Chile | 1 | <1% |
| Singapore | 1 | <1% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 158 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 40 | 24% |
| Researcher | 35 | 21% |
| Student > Master | 20 | 12% |
| Student > Bachelor | 15 | 9% |
| Student > Doctoral Student | 8 | 5% |
| Other | 26 | 16% |
| Unknown | 22 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 50 | 30% |
| Medicine and Dentistry | 30 | 18% |
| Immunology and Microbiology | 27 | 16% |
| Biochemistry, Genetics and Molecular Biology | 21 | 13% |
| Engineering | 7 | 4% |
| Other | 10 | 6% |
| Unknown | 21 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2023.
All research outputs
#4,750,205
of 25,093,754 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#44,617
of 102,347 outputs
Outputs of similar age
#22,226
of 114,661 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#329
of 731 outputs
Altmetric has tracked 25,093,754 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 102,347 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.1. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 114,661 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 731 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.