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Attention Score in Context
| Title |
Genome-wide association study identifies three loci associated with melanoma risk
|
|---|---|
| Published in |
Nature Genetics, July 2009
|
| DOI | 10.1038/ng.411 |
| Pubmed ID | |
| Authors |
D Timothy Bishop, Florence Demenais, Mark M Iles, Mark Harland, John C Taylor, Eve Corda, Juliette Randerson-Moor, Joanne F Aitken, Marie-Francoise Avril, Esther Azizi, Bert Bakker, Giovanna Bianchi-Scarrà, Brigitte Bressac-de Paillerets, Donato Calista, Lisa A Cannon-Albright, Thomas Chin-A-Woeng, Tadeusz Dębniak, Gilli Galore-Haskel, Paola Ghiorzo, Ivo Gut, Johan Hansson, Marko Hočevar, Veronica Höiom, John L Hopper, Christian Ingvar, Peter A Kanetsky, Richard F Kefford, Maria Teresa Landi, Julie Lang, Jan Lubiński, Rona Mackie, Josep Malvehy, Graham J Mann, Nicholas G Martin, Grant W Montgomery, Frans A van Nieuwpoort, Srdjan Novakovic, Håkan Olsson, Susana Puig, Marjan Weiss, Wilbert van Workum, Diana Zelenika, Kevin M Brown, Alisa M Goldstein, Elizabeth M Gillanders, Anne Boland, Pilar Galan, David E Elder, Nelleke A Gruis, Nicholas K Hayward, G Mark Lathrop, Jennifer H Barrett, Julia A Newton Bishop |
| Abstract |
We report a genome-wide association study of melanoma conducted by the GenoMEL consortium based on 317K tagging SNPs for 1,650 selected cases and 4,336 controls, with replication in an additional two cohorts (1,149 selected cases and 964 controls from GenoMEL, and a population-based case-control study in Leeds of 1,163 cases and 903 controls). The genome-wide screen identified five loci with genotyped or imputed SNPs reaching P < 5 x 10(-7). Three of these loci were replicated: 16q24 encompassing MC1R (combined P = 2.54 x 10(-27) for rs258322), 11q14-q21 encompassing TYR (P = 2.41 x 10(-14) for rs1393350) and 9p21 adjacent to MTAP and flanking CDKN2A (P = 4.03 x 10(-7) for rs7023329). MC1R and TYR are associated with pigmentation, freckling and cutaneous sun sensitivity, well-recognized melanoma risk factors. Common variants within the 9p21 locus have not previously been associated with melanoma. Despite wide variation in allele frequency, these genetic variants show notable homogeneity of effect across populations of European ancestry living at different latitudes and show independent association to disease risk. |
Mendeley readers
The data shown below were compiled from readership statistics for 204 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| United Kingdom | 3 | 1% |
| France | 1 | <1% |
| Italy | 1 | <1% |
| Australia | 1 | <1% |
| Germany | 1 | <1% |
| Belgium | 1 | <1% |
| Netherlands | 1 | <1% |
| Japan | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 189 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 46 | 23% |
| Student > Ph. D. Student | 32 | 16% |
| Professor > Associate Professor | 18 | 9% |
| Student > Master | 18 | 9% |
| Professor | 14 | 7% |
| Other | 43 | 21% |
| Unknown | 33 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 63 | 31% |
| Medicine and Dentistry | 49 | 24% |
| Biochemistry, Genetics and Molecular Biology | 45 | 22% |
| Computer Science | 2 | <1% |
| Engineering | 2 | <1% |
| Other | 7 | 3% |
| Unknown | 36 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2009.
All research outputs
#3,515,553
of 25,837,817 outputs
Outputs from Nature Genetics
#3,671
of 7,639 outputs
Outputs of similar age
#13,120
of 127,342 outputs
Outputs of similar age from Nature Genetics
#27
of 52 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,639 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.7. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 127,342 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.