Title |
Antiphospholipid syndrome
|
---|---|
Published in |
Arthritis Research & Therapy, December 2008
|
DOI | 10.1186/ar2536 |
Pubmed ID | |
Authors |
Gerard Espinosa, Ricard Cervera |
Abstract |
Antiphospholipid syndrome is diagnosed when arterial or venous thrombosis or recurrent miscarriages occur in a person in whom laboratory tests for antiphospholipid antibodies (anticardiolipin antibodies and/or lupus anticoagulant and/or anti-beta 2-glycoprotein I) are positive. Despite the strong association between antiphospho-lipid antibodies and thrombosis, their pathogenic role in the development of thrombosis has not been fully elucidated. Novel mechanisms involving both the complement pathway and micro-particles have been described. The knowledge of these new pathogenic approaches might identify novel therapeutic targets and therefore may improve the management of these patients. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Uruguay | 1 | 1% |
Unknown | 89 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 5 | 6% |
Student > Bachelor | 5 | 6% |
Researcher | 5 | 6% |
Professor | 3 | 3% |
Student > Master | 3 | 3% |
Other | 6 | 7% |
Unknown | 63 | 70% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 20% |
Biochemistry, Genetics and Molecular Biology | 4 | 4% |
Agricultural and Biological Sciences | 2 | 2% |
Immunology and Microbiology | 1 | 1% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
Other | 0 | 0% |
Unknown | 64 | 71% |