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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
|
|---|---|
| Published in |
Nature Immunology, July 2008
|
| DOI | 10.1038/ni.1631 |
| Pubmed ID | |
| Authors |
Veit Hornung, Franz Bauernfeind, Annett Halle, Eivind O Samstad, Hajime Kono, Kenneth L Rock, Katherine A Fitzgerald, Eicke Latz |
| Abstract |
Inhalation of silica crystals causes inflammation in the alveolar space. Prolonged exposure to silica can lead to the development of silicosis, an irreversible, fibrotic pulmonary disease. The mechanisms by which silica and other crystals activate immune cells are not well understood. Here we demonstrate that silica and aluminum salt crystals activated inflammasomes formed by the cytoplasmic receptor NALP3. NALP3 activation required phagocytosis of crystals, and this uptake subsequently led to lysosomal damage and rupture. 'Sterile' lysosomal damage (without crystals) also induced NALP3 activation, and inhibition of either phagosomal acidification or cathepsin B activity impaired NALP3 activation. Our results indicate that the NALP3 inflammasome senses lysosomal damage as an endogenous 'danger' signal. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 33% |
| Germany | 1 | 17% |
| Japan | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,037 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 11 | 1% |
| Germany | 6 | <1% |
| United Kingdom | 4 | <1% |
| France | 3 | <1% |
| Australia | 2 | <1% |
| Italy | 2 | <1% |
| Colombia | 2 | <1% |
| Brazil | 2 | <1% |
| Spain | 2 | <1% |
| Other | 11 | 1% |
| Unknown | 992 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 260 | 25% |
| Researcher | 154 | 15% |
| Student > Master | 112 | 11% |
| Student > Bachelor | 108 | 10% |
| Student > Doctoral Student | 65 | 6% |
| Other | 154 | 15% |
| Unknown | 184 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 289 | 28% |
| Immunology and Microbiology | 140 | 14% |
| Medicine and Dentistry | 123 | 12% |
| Biochemistry, Genetics and Molecular Biology | 123 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 35 | 3% |
| Other | 124 | 12% |
| Unknown | 203 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2023.
All research outputs
#1,313,530
of 25,837,817 outputs
Outputs from Nature Immunology
#844
of 4,229 outputs
Outputs of similar age
#3,022
of 97,852 outputs
Outputs of similar age from Nature Immunology
#2
of 35 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,229 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.8. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 97,852 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.