Title |
Two Cases of Refractory Cardiogenic Shock Secondary to Bupropion Successfully Treated with Veno-Arterial Extracorporeal Membrane Oxygenation
|
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Published in |
Journal of Medical Toxicology, February 2016
|
DOI | 10.1007/s13181-016-0539-7 |
Pubmed ID | |
Authors |
C. William Heise, Aaron B. Skolnik, Robert A. Raschke, Huw Owen-Reece, Kimberlie A. Graeme |
Abstract |
Bupropion inhibits the uptake of dopamine and norepinephrine. Clinical effects in overdose include seizure, status epilepticus, tachycardia, arrhythmias, and cardiogenic shock. We report two cases of severe bupropion toxicity resulting in refractory cardiogenic shock, cardiac arrest, and repeated seizures treated successfully. Patients with cardiovascular failure related to poisoning may particularly benefit from extracorporeal membrane oxygenation (ECMO). These are the first cases of bupropion toxicity treated with veno-arterial EMCO (VA-ECMO) in which bupropion toxicity is supported by confirmatory testing. Both cases demonstrate the effectiveness of VA-ECMO in poisoned patients with severe cardiogenic shock or cardiopulmonary failure. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 9 | 41% |
Spain | 1 | 5% |
Netherlands | 1 | 5% |
Unknown | 11 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 11 | 50% |
Practitioners (doctors, other healthcare professionals) | 9 | 41% |
Science communicators (journalists, bloggers, editors) | 2 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 77 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 12 | 16% |
Other | 8 | 10% |
Student > Doctoral Student | 7 | 9% |
Researcher | 7 | 9% |
Student > Master | 7 | 9% |
Other | 14 | 18% |
Unknown | 22 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 32% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 10% |
Nursing and Health Professions | 4 | 5% |
Agricultural and Biological Sciences | 4 | 5% |
Psychology | 4 | 5% |
Other | 6 | 8% |
Unknown | 26 | 34% |