Title |
A matter of time: study of circadian clocks and their role in inflammation
|
---|---|
Published in |
Journal of Leukocyte Biology, February 2016
|
DOI | 10.1189/jlb.3ru1015-451r |
Pubmed ID | |
Authors |
Stuart J. Carter, Hannah J. Durrington, Julie E. Gibbs, John Blaikley, Andrew S. Loudon, David W. Ray, Ian Sabroe |
Abstract |
Circadian rhythms regulate changes in physiology, allowing organisms to respond to predictable environmental demands varying over a 24 h period. A growing body of evidence supports a key role for the circadian clock in the regulation of immune functions and inflammatory responses, which influence the understanding of infections and inflammatory diseases and their treatment. A variety of experimental methods have been used to assess the complex bidirectional crosstalk between the circadian clock and inflammation. In this review, we summarize the organization of the molecular clock, experimental methods used to study circadian rhythms, and both the inflammatory and immune consequences of circadian disturbance. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 10 | 33% |
Argentina | 2 | 7% |
Germany | 2 | 7% |
Mexico | 1 | 3% |
Canada | 1 | 3% |
Brazil | 1 | 3% |
Unknown | 13 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 21 | 70% |
Practitioners (doctors, other healthcare professionals) | 6 | 20% |
Scientists | 2 | 7% |
Unknown | 1 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Singapore | 1 | <1% |
Unknown | 129 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 29 | 22% |
Researcher | 20 | 15% |
Student > Master | 18 | 14% |
Student > Bachelor | 14 | 11% |
Student > Postgraduate | 9 | 7% |
Other | 18 | 14% |
Unknown | 23 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 31 | 24% |
Biochemistry, Genetics and Molecular Biology | 24 | 18% |
Medicine and Dentistry | 22 | 17% |
Neuroscience | 11 | 8% |
Immunology and Microbiology | 7 | 5% |
Other | 9 | 7% |
Unknown | 27 | 21% |